类风湿关节炎患者发生心血管病变的相关危险性因素研究

The Related Risk Factor Research of Rheumatoid Arthritis on Cardiovascular Disease

目的探究类风湿关节炎(RA)患者发生心血管病变的相关危险因素。方法选择149例2014年4月-2016年5月在我院进行治疗的RA患者,根据心脏彩超检查结果,将具有心血管病变的患者设为A组,将不具有心血管病变的患者设为B组,对比两组患者一般资料及实验室检查中具有差异的部分,采用Logistic回归分析探讨RA患者心血管病变的危险因素。结果 149例RA患者中共有32例患有心血管病变,占比为21.48%,设为A组,另有117例患者不患有心血管病变,占比78.52%,设为B组。A、B两组患者在病程、DAS28、TC、CRP以及D-二聚体水平中差异具有统计学意义,P<0.05。将以上有差异资料带入Logistic回归方程中计算,结果发现,病程、DAS28评分、TC、CRP以及D-二聚体均是RA患者心血管病变的危险因素。结论心血管病变在RA患者中较为常见,多因素分析提示RA患者发生心血管病变的风险与病程、TC、CRP以及D-二聚体、DAS28评分有关,对RA患者早期进行全面的体格检查及相关危险因素的检测可降低发生心血管病变的风险。

Objective To explore the related risk factor of rheumatoid arthritis on cardiovascular disease. Methods Chose 149 cases of rheumatoid arthritis patients admitted to our hospital from April 2014 to May 2016 to collect the general information and laboratory examination result. The patients with cardiovascular disease were served as group A and patients without cardiovascular disease were served as group B to compare the different items of general materials regarding two patients. The Logistic regression analysis method was used to investigate the influencing factors of RA patients with cardiovascular disease. Results 32 cases of patients with cardiovascular disease were served as group A accounting for 21.48%, and another 117 cases of patients with no cardiovascular disease were served as group B accounting for 78.52% among 149 cases of patients with RA. It＇s of significance for patients of group A and group B in terms of the levels of course, TC, CRP and D-dimer with P〈0.05. The above mentioned different materials was brought in the Logistic regression equation for calculation. It can be found that the course, DAS28 soccer, TC, CRP and D-dimer were all risk factors of cardiovascular diseases for patients with RA. Conclusion Cardiovascular disease is commonly seen in patients with RA. Multivariate analysis showed that the risk of cardiovascular injury in patients with RA was related to the scores of the course of disease, TC, CRP, D dimer, and DAS28. Early physical examination and related risk factors detection in patients with RA can reduce the risk of cardiovascular damage.