2型糖尿病合并脑干梗死相关危险因素分析

目的分析2型糖尿病合并脑干梗死的危险因素。方法收集2008年9月至2009年3月急性脑干梗死患者共89例，依据是否患有2型糖尿病分为2型糖尿病合并脑干梗死组（n=37）和非糖尿病合并脑干梗死组（n=52），观察收缩压（SBP）、舒张压（DBP）、纤维蛋白原、血浆D-二聚体、糖化血红蛋白（HbA1c）、空腹血糖（FBG）、餐后2h血糖（PBG）、尿酸、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、血同型半胱氨酸（HCY）、超敏C反应蛋白（CRP），分析其危险因素。结果2型糖尿病合并脑干梗死组较非糖尿病合并脑干梗死组的SBP、血浆D-二聚体、FBG、PBG、HbA1C、LDL-C明显升高（P〈0．05）。HbA1C、SBP、PBG、吸烟史是2型糖尿病发生脑干梗死的危险因素（OR值分别为1．18、4．8、2．16、2．12）。结论高血压、糖尿病、高血脂是2型糖尿病合并脑干梗死患者的高危因素；PBG是独立危险因素。

Objective To analyze risk factors of brainstem infarction with type 2 diabetes mellitus. Methods The 89 patients with acute brainstem infarction who were admitted to the neurological department, the Second Affiliated Hospital Of Medicine School, Zhejiang University during September 2008 to March 2009 were studied.They were divided into brainstem infarction with tye 2 diabetes mellitus group （ n=37 ） and brainstem infarction without diabetes group （ n=52 ） according to whether they had rye 2 diabetes mellitus.Diastolic blood pressure （ DBP ） , systolic blood pressure （ SBP ） , fibrinogen, plasma D-dimer, glycosylated hemoglobin （ HbAlc ） , fasting plasma glucose （ FPG ） , 2 hour postprandial blood glucose （ PBG ） , blood uric acid, triglyceride （ TG ） , total cholesterol （ TC ） , high density lipoprotein cholesterol （ HDL-C ） , low density lipoprotein cholesterol （ LDL-C ） , blood homocysteine （ HCY ） , and hypersensitive c-reactive protein （ CRP ） were observed.Risk factors were analyzed. Result Compared with non-diabetic group, SBP, plasma D -dimer, FBG, PBG, HbA1C, LDL-C were significantly higher in tye 2 diabetes mellitus group （ P〈0.05 ） .HbA1C, SBP, PBG, smoking history were the risk predictors of brainstem infarction with tye 2 diabetes mellitus （ OR=1.18, 4.8, 2.16, 2.12 ） .Conclusions The high blood pressure, high blood sugar and smoking history are risk factors ofbrainstem infarction with type 2 diabetes mellitus; PBG is the independent risk factor.