HNP1-3在新生儿败血症诊断中的价值

目的探讨人中性粒细胞多肽1-3（HNP1-3）在新生儿败血症诊断中的价值。方法新生儿败血症患儿105例，在入院初期（急性期）及恢复期（有效抗生素治疗10d左右）行外周血血浆HNP1-3和超敏C-反应蛋白（hs-CRP）测定，取同期出生的新生儿30例作为对照组，一次性采血测定HNP1-3和hs—CRP。结果新生儿败血症急性期组血浆HNP1-3、hs—CRP水平显著高于恢复期组和对照组（P〈0．01），新生儿败血症急性期组血浆HNP1，3水平与hs—CRP水平呈中度正相关关系（r=0．450，P〈0．05）。结论新生儿败血症患儿外周血浆HNP1-3水平明显高于健康新生儿，与hs—CRP呈正相关，HNP1-3对新生儿败血症早期诊断有一定的临床价值。

Objective To explore the neutrophil peptide 1-3 （ HNP 1-3 ） value in the diagnosis of neonatal sepsis. Methods Neonatal sepsis in children with 105 cases, in the early admission （ acute phase ） and recovery （ effective antibiotics around 10 d ） line of peripheral blood plasma HNP 1-3 and allergic C-reactive protein （ hs-CRP ） , 30 cases of newborns in the same period wereas control group, blood smaple were collected once for the determination of blood HNP 1-3 and hs-CRP. Results During acute phase, plasma HNP 1-3, hs-CRP level in neonataleonatal sepsis group acute phase plasma HNP 1-3, hs-CRP level is significantly higher than treatment group and control group （ P〈0.01 ） , neonatal sepsis, acute phase plasma HNP of 1-3 and hs-CRP levels in moderate positive correlation （ r=0.450, P〈0.05 ） .Conclusions Neonat-alsepsis in children with peripheral blood plasma HNP 1-3 level is significantly higher than that of healthy newborn, positively correlated with hs-CRP, HNP 1-3 of neonatal sepsis in early diagnosis has certain clinical value.