心型脂肪酸结合蛋白在脓毒症心肌损伤早期的检测价值

Changes and Significance of Geart-type Fatty Acid-binding Protein and Troponin IPeptide in Sepsis Patients with Myocardium Injury

目的:探讨脓毒症患者心型脂肪酸结合蛋白(heart-type fatty acid-binding protein,H-FABP)心肌损伤变化规律及早期检测的临床应用价值。方法:56例脓毒症患者按脓毒症严重程度分为脓毒症组32例、严重脓毒症组24例;体检者50例为对照组。脓毒症患者入院1 h(发病3 h内)、6 h时,对照组体检时检测H-FAB、肌钙蛋白I(cardiac troponin I,c Tn I)水平、肌酸激酶同工酶MB(creatinekinade isoenzyme-myocardialband,CK-MB)。结果:入院1 h,脓毒症患者H-FABP高于对照组(P<0.05),脓毒症患者6 h H-FABP和c Tn I均高于1 h(P<0.05),1 h、6 h严重脓毒症患者H-FABP均高于脓毒症患者(P<0.05),6 h严重脓毒症患者c Tn I高于脓毒症患者(P<0.05)。结论:H-FABP对脓毒症患者心肌损伤的早期诊断和预后评估有重要意义。

Objective： To investigate the clinical value of heart-type fatty acid-binding protein（H-FABP） in sepsis patients with myocardium injury. Methods： 56 sepsis patients were included as sepsis group（32 cases） and severe sepsis group（24 cases） according to their Severity of illness. 50 healthy people were selected as control group. H-FABP,cardiac troponin I（c Tn I）, creatinekinade isoenzyme（CK- MB） were assessed at 1 h, 6hafter admission by physical examination. Results： At 1h after admission, H-FABP level in sepsis patients were significantly higher than control group（P 0.05）. H-FABP and c Tn I level at 6 h after admission were higher than that at 1 h（P 0.05）. H-FABP and c Tn I level in severe sepsis group were higher than those of sepsis group at 1, 6 h after admission（P 0.05）. c Tn I level at 6 h after admission was higher in sepsis group（P 0.05）. Conclusion： H-FABP may suggest important significance in early diagnosis and prognosis prediction of sepsis patients with myocardium injury.