白介素-6在妊娠糖尿病中的临床观察

Clinical Observation of Interleukin-6 in Gestational Diabetes Mellitus

目的:观察白介素-6(IL-6)在妊娠糖尿病(GDM)中的变化。方法:纳入2014年10月至2015年6月在福州市第一医院门诊就诊的妊娠妇女(孕周不定,妊娠前有糖尿病病史的孕妇排除实验对象),通过OGTT确诊有无妊娠期糖尿病,检测血糖、糖化血红蛋白(Hb A1c)、C反应蛋白(CRP)、白介素-6(IL-6)等相关指标。结果:妊娠糖尿病孕妇空腹血糖、餐后2小时血糖、Hb A1c大于正常组,其中C组、D组的空腹血糖、Hb A1c和A组的差异具有统计学意义(P<0.05);炎症因子方面,妊娠糖尿病孕妇C组、D组CRP高于A组,B组、C组、D组IL-6大于A组。结论:妊娠糖尿病孕妇,特别孕中晚期患者的IL-6水平高于正常妊娠妇女,可能有妊娠糖尿病存在一定的因果关系。

Objective： To observe interleukin-6（IL-6） changes in gestational diabetes mellitus. Methods： The patients of pregnant women were selected of Fuzhou first hospital from October 2014 to June 2015 in outpatient（gestational age uncertain, there is a history of diabetes before pregnancy, pregnant women were excluded）, with or without gestational diabetes diagnosed by OGTT. Glycosylated hemoglobin（Hb A1c）, C- reactive protein（CRP）,interleukin-6（IL-6） and other related indicators were detected. Results： Pregnant women with gestational diabetes fasting blood glucose, 2-hour postprandial blood glucose, Hb A1 c were larger than those of normal group. Fasting blood glucose,Hb A1 c of group C, D were statistically significant compared to group A（P0.05）. In infla mmatory cytokines aspects,CRP of group C and D were higher than that of group A. IL- 6 of group B, C, D were greater than that of group A.Conclusion： Pregnant women with gestational diabetes, particularly in patients with advanced pregnancy, IL-6 levels is higher than normal pregnant women. There may be some causal relationships between the presence of gestational diabetes.