摘要
人乳头瘤病毒(human papilloma virus,HPV)种类繁多,其分类方法也较多。根据易感染的细胞类型、临床表现可以分为皮肤型、疣相关型和黏膜型;依据HPV生物学行为,将其分为高危型和低危型。高危型HPV可导致恶性肿瘤发生,比如HPV16和18型是导致大部分宫颈癌发生的高危型别。与HPV相关的其他癌症如口咽癌、非黑素瘤性皮肤癌的高危亚型也是近年来的研究热点。对HPV致病机制的研究促进了人类对癌症发病机制及诊断治疗的认识,预防性HPV疫苗的应用,不仅使宫颈癌成为第一个可以被预防的癌症,也有效的预防了性传播疾病尖锐湿疣的发生。本文着重概述HPV的致病特点及解答临床常见问题。
Human papilloma virus（HPV） features a great variety of species and classifications.Sorted by susceptible cell types,its clinical manifestations can be skin-related,wartrelated or mucosa-related.Classified by its biological behavior,it can be high-risk or low risk.High-risk HPV could cause malignancies,for example,HPV16 and HPV18 are the high-risk species causing most cervical carcinoma.Other HPV-related carcinomas,such as oropharyngeal carcinoma and non-melanoma skin cancers on high-risk HPV have been research focus over years.Research on HPV pathogenesis advanced our knowledge on the pathogenesis,diagnosis and treatment of cancers.Advent of prophylactic HPV vaccine made cervical cancer the first preventable cancer,and also prevented the occurrence of sexually transmitted condyloma acuminata.This article reviews the prevention of HPV pathogenic characteristics and answers to frequentlyasked questions about its clinical issues.
出处
《中国医学文摘（皮肤科学）》
2017年第1期96-101,共6页
China Medical Abstracts(Dermatology)
