北五味子单方提取物在抗结核治疗中对肝功能的保护作用

Protection of Unilateral Extract of Schisandra on Liver Function During anti-TB Therapy

目的探析北五味子单方提取物在抗结核治疗中对肝功能的保护作用,为临床制定预防抗结核化疗所致的肝损伤方案提供参考。方法选择不同治疗期间的388例结核治疗患者,分为治疗组和对照组,治疗组予北五味子单方提取物联合抗结核药方案(2HRZE(S)/4HRE)治疗,对照组抗结核方案与治疗组相同,并予口服葡醛内酯片护肝。治疗结束后,比较2组患者体征、肝功能情况以及临床症状。结果治疗组肝损害轻度发生率要显著高于对照组,中度与重度发生率明显低于对照组,两组比较差异有统计学意义(均P<0.05);肝损伤发生率、发生时间及痊愈率、治疗死亡率、肝硬化、肝功能衰竭以及停止抗结核治疗率等指标两组比较差异有统计学意义(均P<0.05);结论在抗结核药物治疗中,联合北五味子单方提取物可有效保护肝功能,预防药物所致肝损伤,不良反应小,可作为优质方案在临床应用。

OBJECTIVE To explore the protective effect of unilateral extract of Schisandra on liver function during anti-TB therapy, and provide reference for clinical use. METHODS A total of 388 tuberculosis patients were divided into experimental group and control group. Patients in the experimental group received unilateral extract of Schisandra combined with anti- tuberculosis Programed 2HRZE （S）/4HRE treatment. As for the control group, patients were treated with the same anti-tuberculosis program and oral Glucurolactone. Signs, liver function and clinical symptoms in the two groups were evaluated and compared. RESULTS The incidence of moderate and severe liver injury in the experimental group was significantly lower than the control group （P〈0.05）. In addition,the incidence rate, occurrence time and cure rate of liver injury in the two groups were significantly different （ P 〈 0.05 ）. Moreover,the mortality rate, liver cirrhosis rate, liver failure rate and the rate of stop anti-TB treatment were significantly different between the two groups （P〈0.05）. CONCLUSION The combination of unilateral extract of Schisandrai with anti-TB treatment can effectively protect liver injury in tuberculosis patients.