中医药对晚期非小细胞肺癌患者血清肿瘤标志物的干预作用

Intervention Effects of Traditional Chinese Medicine on the Serum Tumor Markers of the Patients with Advanced Non Small Cell Lung Cancer

目的:观察和分析中医药对晚期非小细胞肺癌(NSCLC)患者血清肿瘤标志物的干预作用。方法:选取100例晚期NSCLC患者作为研究对象,根据治疗方法将其分为中医治疗组(46例)和中西医治疗组(54例),中医治疗组患者应用单纯中医药综合治疗方案进行治疗,中西医治疗组患者应用中西医结合治疗方案进行治疗。对两组患者治疗前、治疗第2个月、治疗第4个月、治疗第6个月的血清癌胚抗原(CEA)、糖蛋白抗原125(CA-125)、细胞角蛋白19可溶性片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)水平及疗效、总生存期(OS)进行观察和比较。结果:在治疗第4个月、第6个月,中医治疗组患者的CEA水平均显著低于中西医治疗组,差异均有统计学意义(t=-3.000、-3.383,P<0.05);中医治疗组患者在治疗第2个月时的血清CA125水平显著高于中西医治疗组,在治疗第6个月时的血清CA125水平显著低于中西医治疗组,差异均有统计学意义(t=3.225、-2.831,P<0.05);在治疗第2个月、第4个月,中西医治疗组患者的血清CYFRA21-1水平均显著低于中医治疗组,差异均有统计学意义(t=3.130、3.113,P<0.05)。结论:在晚期NSCLC治疗中,应用单纯中医治疗方案和中西医治疗方案可获得相当的近期疗效和生存时间,但应用单纯中医治疗能够更好地维持晚期NSCLC患者肿瘤标志物水平的稳定,有助于维持肿瘤病情的相对稳定。

Objective：To observe and analyze the intervention effects of traditional Chinese medicine on the serum tumor markers of the patients with advanced non small cell lung cancer （NSCLC）. Methods ： A total of 100 cases of advanced NSCLC patients were selected as the research objects and divided into the traditional Chinese medicine treatment group （46 cases） and the tradi- tional Chinese medicine combined with western medicine treatment group （54 cases） according to the treatment plan. The patients in the traditional Chinese medicine treatment group were treated with single comprehensive traditional Chinese medicine treat- ment, while the patients in the traditional Chinese medicine combined with western medicine treatment group were treated with the traditional Chinese medicine combined with western medicine treatment. The serum carcinoembryonic antigen （ CEA）, carbohy- drate antigen 125 （CA - 125 ）, cytokeratins 19 soluble fragment （ CYFRA21 - 1 ）, neuron specific enolase （NSE） levels before the treatment and at 2nd month,4th month,6th month of the treatment and the clinical therapeutic effects, the overall survival （OS） of the patients in the two groups were observed and compared. Results：At 4th month,6th month of the treatment, the serum CEA levels of the patients in the traditional Chinese medicine treatment group were significantly lower than those in the traditional Chi- nese medicine combined with western medicine treatment group, the differences were statistically significant （ t = - 3. 000, - 3. 383, P 〈 0.05 ）. The serum CA125 level at 2nd month of the treatment of the patients in the traditional Chinese medicine treatment group was significantly higher than that in the traditional Chinese medicine combined with western medicine treatment group, the serum CA125 level at 6th month of the treatment of the patients in the traditional Chinese medicine treatment group was significantly lower than that in the traditional Chinese medicine combined with western medicine treatment group, the differences were statistically significant （t = 3. 225, -2. 831 ,P 〈 0.05）. At 2nd ,4th month of the treatment,the serum CYFRA21 -1 levels of the patients in the traditional Chinese medicine combined with western medicine treatment group were significantly lower than those in the traditional Chinese medicine treatment group, the differences were statistically significant （ t = 3.130,3.113, P 〈 0.05 ）. Conclusion：In the treatment of advanced NSCLC, the application of single traditional Chinese medicine treatment or the traditional Chinese medicine combined with western medicine treatment can achieve equal therapeutic effects and survival time. However, the application of single traditional Chinese medicine treatment can maintain the stability of the serum tumor markers levels in the patients with advanced NSCLC more significantly,which helps to maintain the relatively stable of tumor condition.