巨噬细胞与动脉粥样硬化及中医药干预作用研究进展

Research Progress of Macrophages and Atherosclerosis and the Intervention of Traditional Chinese Medicine

动脉粥样硬化是全球的常见病、多发病,同时是导致心脑血管疾病的主要的病理基础,严重影响到人类生命健康。AS一个慢性炎性反应的过程,高脂血症、高血压、高血糖、高尿酸、肥胖等多种因素导致血管内皮损伤,血管壁增厚,弹性改变等一系列变化。在AS发生的不同阶段,巨噬细胞凋亡、自噬分别发挥着不同的作用,以及不同表型的巨噬细胞在AS的进程中也发挥着不同作用,适度的凋亡和自噬会降低炎症反应发生,保证AS斑块的稳定性,将M1型巨噬细胞向M2型巨噬细胞极化亦会增强AS斑块的稳定性,减少临床不良事件的发生。文章就巨噬细胞凋亡、自噬和极化等与AS发生发展的关系以及中医药干预作用研究进展作一综述,为临床防治AS以及新药研发提供新的理论依据。

Atherosclerosis is a common and frequently - occurring disease in the world, and the main pathological basis of cardiovascular and cerebrovascular diseases, seriously affecting human life and health. AS a chronic inflammatory response process, hyperlipidemia, hypertension, high blood sugar, high uric acid, obesity and other factors lead to vascular endothelial inju- ry, vascular wall thickening, elastic changes, such as a series of changes. Macrophage apoptosis and autophagy play different roles respectively, at different stages of AS, and different phenotypes of macrophages also play different roles, moderate apoptosis and autophagy can decrease the inflammatory reaction and ensure the stability of AS plaques ,the polarization of MI type macrophages to M2 macrophages also enhanced the stability of AS plaque, reduced the incidence of clinical adverse events. In this paper, the relationship between macrophage apoptosis ,autophagy,polarization and the development of AS and the research progress of tradi- tional Chinese medicine intervention are summarized to provide a new theoretical basis for the prevention and treatment of AS and the development of new drugs.