乳酸菌源纳米硒对小鼠生长与繁殖性能影响

Effect of LA4 lactic acid bacterially synthesized Se nanoparticles on Growth and Reproduction Performance in mice

硒是重要的微量元素,纳米硒具有更好的生物学功能,且毒性显著低于无机硒。通过对昆明系小鼠灌胃不同浓度乳酸菌源纳米硒进行试验:对照组,0.2mg·kg-1纳米硒组,0.5mg·kg-1纳米硒组,1.0mg·kg-1纳米硒组,研究分析此纳米硒对小鼠生长与繁殖性能的影响。纳米硒添加水平在0.5mg·kg-1时,对小鼠促生长与繁殖性能效果最明显,此时小鼠日增重提高了24.88%(P<0.01),料重比降低了23.34%(P<0.01),小鼠的平均产仔率提高了40.00%,产仔窝数比对照组提高了40.00%,同时平均每窝产仔数也提高了11.44%;结合纳米硒使小鼠全血、睾丸中谷胱甘肽过氧化物酶(GSH-PX)的活力分别提高了19.27%(P<0.01)、90.68%(P<0.01)的影响以及GSH-PX在动物繁殖性能方面的重要性,可以推断该乳酸菌源纳米硒能够明显提高小鼠的生长与繁殖性能。

Selenium is an important trace element in human body, and Nano-Se has better biological function and lower toxicity than inorganic selenium. This study prepared Nano-Se by synthesized by a strain of lac- tic acid. The Kunming mice were given with 0,0.2,0. 5 and 1.0 mg ·kg ^-1 . bw Nano-Se to study the effect of Nano-Se on growth and reproduction performance of mice. The results showed that the best growth and reproduction performance of mice was with 0.5 mg/kg · bw Nano-Se,the daily weight gain of mice increased by 24.88% （P〈0.01） ,material weight ratio was reduced by 23.34%（P〈0.01） ,mice av- erage farrowing rate increased by 40.0%, litter number increased 40.0%compared with control group, meanwhile, the average born number also increased 11.44 per litter, Nano-Se could improve the activity of glutathione peroxidase （GSH-PX） in whole blood to 19.27% （P〈0.01） and testis of mice to 90. 68% （P 〈0.01） respectively. In conclusion,Se Nano-particles synthesized by LA4 lactic acid could improve the growth and reproduction performance in mice.