降钙素原在新生儿败血症中的应用

Application of procalcitonin in neonatal sepsis

目的在新生儿败血症诊断中应用降钙素原的临床价值。方法选取50例于2015年6月~2016年6月期间我院接收的败血症患儿作为观察组,同时选取同期入院无感染症状的新生儿50例作为对照组,在抗生素应用前、应用后1周检测降钙素原、白细胞计数、超敏C反应蛋白。结果观察组患儿PCT水平、WBC及CRP水平均显著高于对照组（P〈0.05）;且观察组PCT阳性率、CRP阳性均显著高于对照组（P〈0.05）;PCT的敏感性、阳性预测值、特异性、阴性预测值均优于CRP;观察组恢复期CRP、PCT值均显著降低,明显低于治疗前（P〈0.05）。结论血清降钙素原在新生儿败血症的早期诊断和疗效观察中有重要价值,具有推广价值。

Objective To explore the The clinical application value of procalcitonin in neonatal sepsis.Methods 50 cases of sepsis patients cured in our hospital from June 2015 to July 2016 were selected as observation group,and 50 cases of patients admitted to hospital at the corresponding period were selected as control group.Procalcitonin,white blood cell count,and super C-reactive protein were tested before and after the one-week application of antibiotic.Results The levels of PCT,WBC and CRP in the observation group were significantly higher than those in the control group（P〈0.05）.The PCT positive rate,and CRP positive rate in the observation group were significantly higher than those in the control group（P〈0.05）.The sensitivity,positive predictive value,specificity and negative predictive value of PCT were better than those of CRP.The values of PCT and CRP in the recovery phase for observation group were significantly lower than those of prior-treatment（P〈0.05）.Conclusion Serum procalcitonin has promotional value in the early diagnosis and clinical observation of neonatal sepsis.It has the promotion value.