糖皮质激素诱导肾阳虚抑郁症动物模型研究进展

Research progress of depression animal models with kidney-yang deficiency induced by glucocorticoid

临床上,肾阳虚是抑郁症患者的主要中医证型之一,针对肾阳虚抑郁症患者采用温补肾阳的方法取得较好疗效,但针对肾阳虚型抑郁症动物模型的复制方法尚无明确统一的规定和标准,为肾阳虚型抑郁症的研究带来困扰,因此,为了进一步完善肾阳虚型抑郁症动物模型的复制方法,现对近十五年来采用糖皮质激素类药物诱导的肾阳虚型抑郁症动物模型的造模方法及评价指标进行系统分析,比较异同,为肾阳虚抑郁症的合理造模提供参考依据。

Clinically,kidney-yang deficiency is one of the main TCM syndromes in patients with major depressive disorder. Warming yang and reinforcing kidney as a therapeutic measure for the treatment of depressive disorder has achieved good clinical curative effect. However,there are some problems on the study of kidney-yang deficiency depression.One of the reasons is that the establishment methods of depression animal model with kidney-yang deficiency are not unified. In order to provide reference and further improve the replication method of depression animal models with kidney-yang deficiency,we systematically collected and analyzed the experiment results published in the past 15 years about the depression animal model with kidney-yang deficiency induced by glucocorticoid hormone drugs and find out their similarities and differences.