整合素αv在食管鳞状细胞癌组织中的表达及其临床意义

The expression and the clinical pathology of integrin αv in esophageal squamous cell carcinoma tissues

目的:研究整合素αv在食管鳞状细胞癌组织中的表达及其临床意义。方法:应用免疫组织化学染色检测58例食管鳞状细胞癌和17例癌旁组织整合素αv的表达,分析整合素αv的表达与临床病理特征之间的相关性。结果:整合素αv在食管鳞状细胞癌组织的表达率(77.59%)显著高于癌旁组织(5.88%),整合素αv的表达与T、N分期及临床分期相关,与患者年龄、性别无关。结论:整合素αv与食管鳞状细胞癌的转移和发展有关。

Objective： To evaluate the correlation between integrin αv expression and metastasis and progression in Esophageal squamous cell carcinoma. Methods： Immunohistochemical staining were performed to detect the expression of integrin αv in 58 Esophageal squamous cell carcinoma tissue samples and 17 adjacent tissue samples. The correlation between the integrin αv expression and clinicopathological factors was evaluated. Results： In Esophageal squamous cell carcinoma tissues, the expression rates of integrin αv protein was 77.59%, significantly higher than that in adjacent tissue samples（5.88%, P〈0.05）. It was also observed that the protein expression of integrin αv was significantly related to T, N and clinical stages（all P〈0.05）. Conclusions： All these findings suggest that overexpression of integrin αv is closely associated with metastasis and progression of Esophageal squamous cell carcinoma. Therefore, it can be speculated that integrin αv could be a effective biomarker for individualized treatment of patients with Esophageal squamous cell carcinoma.