清脑方联合疏血通注射液对急性脑梗死患者HCY及D-二聚体含量的影响

Influence of Qingnao Decoction and Shuxuetong Injection on hyperhomocysteinemi and D-dimer in patients with acute cerebral infarction

目的观察清脑方联合疏血通注射液治疗急性脑梗死的作用机制。方法将60例急性脑梗死患者随机分为治疗组和对照组(各30例);两组均给予西医常规治疗,对照组同时行疏血通注射液静脉滴注,治疗组在对照组基础上口服清脑方,疗程14 d。观察两组治疗前后神经功能缺损评分(NIHSS评分)、巴氏日常生活指数(BI)变化,检测血清同型半胱氨酸(HCY)和D-二聚体变化。结果 (1)治疗后,两组患者NIHSS评分均较治疗前显著降低(P<0.01),且治疗组低于对照组(P<0.05);(2)治疗后,两组患者BI指数均较治疗前显著升高(P<0.01),且治疗组高于对照组(P<0.05);(3)治疗后,两组患者血清HCY含量和D-D含量均较治疗前降低(P<0.05,P<0.01),且治疗组低于对照组(P<0.05)。结论清脑方联合疏血通注射液治疗急性脑梗死临床疗效良好,其机制与降低血清HCY和D-二聚体含量有关。

Objective To observe the clinical effect of Qingnao Decoction combined with Shuxuetong Injection in the treatment of acute cerebral infarction and its mechanism. Methods 60 cases of acute cerebral infarction were randomly divided into the treatment group and control group （ 30 cases in each group） ; both groups were received conventional treatment of western medicine, while the control group was treated with Shuxuetong Injection for intravenous infusion, the treatment group was treated orally with Qingnao Decoction based on the treatment for the control group, with a course of 14 days. The changes of National Institutes of Health Stroke Scale （NIHSS） and Barthel Index （BI） in both groups were observed before and after treatment, and the changes of hyperhomocysteinemi（HCY） and D-dimer were detected. Results （1） After treatment, the NIHSS score in both groups were significantly decreased compared with treatment before （ P 〈0.01 ） ,and the score of the treatment group was lower than that of the control group （ P 〈 0.05 ） ; （2）After the treatment, the BI in both groups were significantly increased compared with treatment before （ P 〈0.01 ）, and the index of the treatment group was higher than that of the control group （ P 〈 0.05 ） ; （3）After treatment, the serum contents of HCY and D-dimer in both groups were decreased compared with treatment before （P 〈0.05,P 〈0.01 ）, and the contents of the treatment group were lower than those of the control group （P 〈0.05 ）. Conclusion Qingnao Decoction combined with Shuxuetong Injection shows good effects in the treatment of acute cerebral infarction, its mechanism may be related to reducing the serum contents of HCY and D-dimer.