癫癎患者血尿酸水平检测及相关性分析

Level of Uric Acid and Its Relevant Factors in Epilepsy Patients

目的:检测癫癎患者血清尿酸代谢水平并分析可能的影响因素。方法:选取癫癎患者136例,另选同期健康体检者34例为对照;检测并比较两组血尿酸水平;分析与尿酸水平相关因素。结果:癫癎组血尿酸水平(392.5μmol/L)较对照组(326.6μmol/L)明显升高(P<0.001);癫癎组中3 d内有发作者尿酸水平(417.8μmol/L)较无发作者(319.5μmol/L)明显升高(P<0.001)。癫癎组血尿酸水平与血尿素氮(r=0.317),肌酐(r=0.528),WBC(r=0.301),血红蛋白(r=0.305),肌酸激酶(r=0.295),同型半胱氨酸(r=0.288)水平正相关;与高密度脂蛋白胆固醇(r=-0.242)水平负相关。此外,其与发作类型(r=-0.285)及性别(r=0.368)相关。结论:癫癎患者血尿酸水平明显升高,与发作状态、生化代谢有关。

Objective：To detect the serum level of uric acid in epilepsy patients,and to analyze its relevant factors. Methods：One hundren and thirty-six epilepsy patients and 34 healthy cases were enrolled. The serum level of uric acid between two groups was detected and compared,and the relative factors with level of uric acid were analyzed. Results：The level of uric acid（392.5 μmol/L）in the epilepsy group was higher than that in the control group（326.6 μmol/L）（P〈0.001）. The level of uric acid（417.8 μmol/L）of epilepsy patients within 3 days in the epilepsy group was higher than that（319.5 μmol/L）in the non-epilepsy patients（P〈0.001）. The level of uric acid in the epolepsy group was positively correlated with the levels of blood urea nitrogen（r=0.317）,creatinine（r=0.528）,WBC（r=0.301）,hemolglobin（r=0.305）,creatine kinase（r=0.295）,homocysteine（r=0.288）,and negatively correlated with the level of high-density lipoprotein cholesterol（r=-0.242）. In addition,the level of uric acid was associated with the type of epilepsy（r=-0.285）and genders（r=0.368）. Conclusion：The level of uric acid in epilepsy patients is significantly elevated,and correlated with seizure state and biochemical metabolism.