鹿血晶联合GP方案治疗晚期非小细胞肺癌化疗后血小板减少的临床观察

Clinical observation of cervus blood granule combined with GP in the treatment of advanced non-small cell ;lung cancer after chemotherapy

目的：探讨中药鹿血晶联合GP方案对晚期非小细胞肺癌患者化疗后血小板的影响。方法80例晚期非小细胞肺癌患者按数字表法随机分为两组，联合组40例给予中药鹿血晶联合标准GP方案治疗，对照组40例给予标准GP方案治疗，检测两组化疗第7天及第10天血常规，记录血小板数值，比较两组血小板减少发生情况。结果化疗第7天，对照组发生Ⅰ度血小板减少5例，Ⅱ度血小板减少2例，Ⅲ度血小板减少1例，Ⅳ度血小板减少1例；联合组发生Ⅰ度血小板减少3例，Ⅱ度血小板减少1例，无Ⅲ度或Ⅳ度血小板减少发生，两组差异无统计学意义（Z＝－1．259，P＝0．208）。至化疗第10天，对照组发生Ⅰ度血小板减少6例，Ⅱ度血小板减少3例，Ⅲ度血小板减少1例，Ⅳ度血小板减少1例；联合组发生Ⅰ度血小板减少4例，Ⅱ度血小板减少1例，无Ⅲ度或Ⅳ度血小板减少发生。两组差异有统计学意义（Z＝－1．966，P＝0．049）。结论中药鹿血晶联合GP方案治疗晚期非小细胞肺癌可有效降低化疗所致血小板减少分级，并在一定程度上预防血小板减少的发生。

Objective To discuss the efficacy of GP combined with cervus blood granule in treating advanced non -small cell lung cancer （NSCLC ） after chemotherapy.Methods Eighty patients with advanced NSCLC were randomly divided into two groups by digital table method.In the combined group,forty patients were trea-ted by GP combined with cervus blood granule.In the control group,forty patients were treated by GP alone.All the patients were tested routine blood in the seventh and tenth day.The value of platelet was recorded,the incidence of thrombocytopenia between two groups was compared.Results At the seventh day of chemotherapy,in the control group,thrombocytopenia Ⅰ found in 5 cases,2 cases of thrombocytopeniaⅡ,1 case of thrombocytopeniaⅢ,thrombo-cytopenia Ⅳ in 1 case.In the combined group,thrombocytopenia Ⅰ occurred in 3 cases,1 case of thrombocytopeniaⅡ,no grade 3 or 4 thrombocytopenia,there was no statistically significant difference between the two groups（Z=-1.259,P=0.208）.At the tenth day of chemotherapy,in the control group,thrombocytopenia Ⅰ found in 6 cases, 3 cases of thrombocytopenia Ⅱ,1 case of thrombocytopenia Ⅲ,thrombocytopenia Ⅳ in 1 case.In the combined group,4 cases occurred thrombocytopenia Ⅰ,thrombocytopenia Ⅱ in 1 case,no grade 3 or 4 thrombocytopenia.The difference between the two groups was statistically significant（Z=-1.966,P=0.049）.Conclusion Cervus blood granule combined with GP can effectively reduce the classification of thrombocytopenia caused by chemotherapy.To some extent,it can also prevent the happening of the thrombocytopenia.