泪点栓塞对干眼患者泪液质量的影响

The Effect of Lacrimal Punctum Embolization on Tear Film Quality of the Patients with Dry Eye

目的通过比较干眼患者上下泪点栓塞术前、术后1月、3月后的泪膜破裂时间及Schirmer I实验,分析上下泪点栓塞对干眼患者泪液质量的影响。方法前瞻性队列研究,选取在北京大学深圳医院就诊的干眼患者31例(42只眼),测量术前、术后1月、3月后的泪膜破裂时间及Schirmer I实验,将所得数据进行单因素方差分析。结果术前、术后1月、术后3月BUT平均值分别为(4.12±1.57)秒、(8.33±1.62)秒、(7.67±1.60)秒,三组数据组间差异有统计学意义(P<0.005),进一步两两比较显示,术前组的BUT值显著小于术后1月组(P<0.005),术前组的BUT值显著小于术后3月组(P<0.005),术后3月组的BUT值显著小于术后1月组(P<0.005);术前、术后1月、术后3月Schirmer I实验平均值分别为(3.47±0.48)mm、(7.88±2.49)mm、(6.99±2.00)mm,三组数据组间差异有统计学意义(P<0.005),进一步两两比较显示,术前组的BUT值显著小于术后1月组(P<0.005),术前组的BUT值显著小于术后3月组(P<0.005),术后3月组的BUT值显著小于术后1月组(P<0.005)。结论上下泪小点栓塞可明显增加干眼患者的Schirmer I实验,泪膜稳定性明显改善,但随时间延长有所下降。

Obiective By comparing the break-up time and SchirmerⅠ test of dry eye patients before and after 1 and 3 month of lacrimal punctum embolization.,Analyze the influence of lacrimal punctum embolization on the patients with dry eye tear quality. Methods In this prospective cohert study, 31 dry eye patients （42 eyes） from Peking University ShenZhen Hospital. Break-up time and SchirmerⅠ test were tested at before and after 1 and 3 month of lacrimal punctum embolization. A one-way ANOVA was used for data analysis. Results The mean BUT of dry eye patient before and after 1 and 3 month of lacrimal punctum embolization, （4.12±1.57）S, （8.33±1.62）S, （7.67±1.60）S,respectively. The difference between the three datas was statistically significant （P〈0.005）. Further comparison each others shows, BUT value of preoperative group significantly less than group 1 month after surgery （P〈0.005）, BUT value of preoperative group significantly less than group 3 month after surgery （P〈0.005）, BUT value of group 1 month after surgery significantly less than group 3 month after surgery （P〈0.005）. The mean Schirmer Ⅰ test of dry eye patient before and after 1 and 3 month of lacrimal punctum embolization, （3.47±0.48）mm, （7.88±2.49）mm, （6.99±2.00） mm,respectively. The difference between the three datas was statistically significant （P〈0.005）. Further comparison each others shows, Schirmer Ⅰ value of preoperative group significantly less than group 1 month after surgery （P〈0.005）, Schirmer Ⅰ value of preoperative group significantly less than group 3 month after surgery （P〈0.005）, SchirmerⅠ value of group 1 month after surgery significantly less than group 3 month after surgery （P〈0.005）. Conclusion Influence of lacrimal punctum embolization can obviously increase the SchirmerⅠ test in patients with dry eye, appears stability obviously improved,But with the extension of time.