S-100蛋白、NSE及MBP在病毒性脑炎患儿中的检测意义

The detection significance of S-100 protein,NSE and MBP in children with viral encephalitis

目的探讨脑脊液(CSF)及血清中S-100蛋白、神经特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)在病毒性脑炎(VE)患儿中的检测价值。方法选取在医院接受治疗的58例VE患儿为VE组,另选取同期40例健康儿童为对照组。根据VE患儿的病情进展分为危急重症组(ESVE组)25例和重症组(SVE组)33例两组,根据VE患儿的预后情况分为预后差组(BP组)21例和预后良好组(GP组)37例两组。比较VE组与对照组、SVE组与ESVE组、BP组与GP组间CSF及血清中S-100、NSE、MBP的水平,并分析联合检测S-100、NSE及MBP在VE患儿中的应用价值。结果 VE组患儿CSF及血清中S-100、NSE、MBP水平均显著高于对照组,SVE组患儿CSF及血清中S-100、NSE、MBP水平均显著低于ESVE组,GP组患儿CSF及血清中S-100、NSE、MBP水平均显著低于BP组,差异均有统计学意义(P<0.01)。联合检测S-100、NSE及MBP的阴性预测值(NPV)、阳性预测值(PPV)、灵敏性均较单一检测项高,差异均有统计学意义(P<0.05)。结论检测CSF及血清中S-100、NSE、MBP的表达水平有助于准确判断VE患儿的病情进展及其预后情况,且3项指标联合检测的诊断价值较高,值得推广。

Objective To explore the detection significance of cerebrospinal fluid（ CSF） and serum S- 100 protein,neuron-specific enolase（ NSE） and myelin basic protein（ MBP） in children with viral encephalitis（ VE）.Methods Fifty-eight children with VE receiving treatment in the hospital were selected as VE group,forty healthy children during the same period were chosen as control group.The children with VE were divided into emergency and severe VE group（ ESVE group,25 children） and severe VE group（ SVE group,33 children）according to the condition of disease.The children with VE were divided into bad prognosis group（ BP group,21 children） and good prognosis group（ GP group,37 children） according to the prognosis.The levels of S- 100 protein,NSE,MBP in CSF and serum between VE group and control group,SVE group and ESVE group,BP group and GP group were compared.The application value of joint detection of S-100 protein,NSE and MBP in VE children was analyzed.Results The levels of S-100 protein,NSE and MBP in CSF and serum in VE group were significantly higher than those in control group,the levels of S-100 protein,NSE and MBP in SVE group were significantly lower than those in ESVE group,the levels of S-100 protein,NSE and MBP in GP group were significantly lower than those in BP group,there were statistically significant differences（ P〈0.01）.The negative predictive value（ NPV）,positive predictive value（ PPV） and sensitivity of joint detection of S-100 protein,NSE and MBP were statistically significantly higher than those of single detection in VE children（ P〈0.05）.Conclusion The detection of S-100 protein,NSE and MBP in CSF and serum can accurately predict the condition and prognosis of VE children.The diagnostic value of joint detection of S-100 protein,NSE and MBP in VE children is higher,which is worthy of promotion.