妊娠早期血清hCG、PROG、E_2水平与流产及胚胎停育的相关性分析

Analysis on the correlations between serum hCG,PROG,E_2 levels and abortion,embryo damage during early pregnancy

目的探讨妊娠早期血清人绒毛膜促性腺激素(hCG)、孕酮(PROG)、雌二醇(E_2)水平与流产及胚胎停育的相关性,为诊断胎儿发育异常提供依据。方法选取2015年1月-2016年1月于济南市第五人民医院门诊进行常规孕前检查的妊娠早期孕妇200例,根据妊娠结局将其分为早期正常妊娠组(172例)、流产组(18例)、胚胎停育组(10例),应用化学发光分析法对孕妇血清hCG、PROG、E_2水平进行检测,对不同妊娠结局组孕妇血清hCG、PROG、E_2水平的差异进行比较。结果与早期正常妊娠组孕妇比较,流产组与胚胎停育组孕妇血清hCG、PROG、E_2水平均明显降低,差异具有统计学意义(P<0.05);与流产组孕妇比较,胚胎停育组孕妇血清hCG、PROG、E_2水平均明显降低,差异具有统计学意义(P<0.05)。经对妊娠早期孕妇血清hCG、PROG、E_2水平进行相关性分析,结果显示流产组孕妇血清hCG水平与PROG水平呈显著正相关(P<0.05),其他组孕妇血清激素水平均无显著相关性(P>0.05)。结论合适的血清hCG、PROG、E_2水平是维持孕妇早期妊娠的重要因素,妊娠早期血清hCG、PROG、E_2水平降低与流产及胚胎停育具有一定的相关性,通过监测血清hCG、PROG、E_2水平有助于预测孕妇妊娠结局。

Objective To explore the correlations between serum human chorionic gonadotropin（ hCG）,progesterone（ PROG）,estradiol（ E_2） levels and abortion,embryo damage during early pregnancy,provide a basis for diagnosing fetal dysplasia.Methods A total of200 early pregnant women receiving conventional prepregnancy examination in the hospital from January 2015 to January 2016 were selected,then they were divided into normal early pregnancy group（ 172 women）,abortion group（ 18 women） and embryo damage group（ 10women） according to pregnancy outcomes,chemiluminescence was used to detect the levels of serum hCG,PROG and E_2,the results in the three groups were compared.Results Compared with normal early pregnancy group,the levels of serum hCG,PROG,E_2 in abortion group and embryo damage group decreased significantly（ P〈0.05）; compared with abortion group,the levels of serum hCG,PROG,E_2 in embryo damage group decreased significantly（ P〈0.05）; correlation analysis showed that serum hCG level was significantly positively correlated with serum PROG level in abortion group（ P〈0.05）,there was no correlation in the other two groups（ P〈0.05）.Conclusion The appropriate levels of serum hCG,PROG,E_2 are important factors to maintain the pregnant women in early pregnancy,the decrease of serum hCG,PROG,E_2 levels in early pregnancy is correlated with abortion and embryo damage to a certain extent,monitoring serum hCG,PROG,E_2 levels can help predict pregnancy outcomes.