平阳霉素碘化油乳化剂与聚乙烯醇颗粒对子宫肌瘤栓塞的疗效对比

Comparison of curative effects of pingyangmycin lipiodol emulsion and polyvinyl alcohol particles in embolizing uterine fibroids

目的通过比较分析栓塞剂平阳霉素碘化油乳化剂(PLE)及聚乙烯醇(PVA)颗粒在子宫肌瘤动脉介入治疗中的效果,为临床介入治疗栓塞剂的选择提供理论基础。方法选取2011年4月-2014年2月在该院就诊的40例子宫肌瘤患者为研究对象,随机分为PLE组和PVA组,每组20例。分别应用PVA、PLE两种栓塞剂进行动脉栓塞,观察子宫肌瘤瘤体大小变化和临床症状缓解情况。结果栓塞术后6个月、12个月、18个月时,两组患者子宫肌瘤体积均显著缩小,与术前相比,差异均有统计学意义(P<0.001);各时间点两组瘤体缩小百分比比较,差异无统计学意义(P>0.05);治疗过程中均无严重并发症发生。结论 PLE乳剂和PVA颗粒均是良好的子宫动脉栓塞剂,二者疗效相当。

Objective To compare and analyze the clinical effects of pingyangmycin lipiodol emulsion（ PLE） and polyvinyl alcohol（ PVA） particles in uterine fibroids embolization（ UAE）, provide a theoretical basis for clinical choice of embolization agent.Methods Forty patients with uterine fibroids were selected from the hospital from April 2011 to February 2014,then they were randomly divided into PLE group and PVA group,20 patients in each group,the patients in the two groups were treated by PVA particles and PLE respectively.The change of uterine fibroids size and remission of clinical symptoms were observed.Results After 6 months,12 months and18 months of embolization,the volumes of uterine fibroids decreased significantly in PLE group and PVA group,compared with before embolization,there was statistically significant difference（ P〈0.001）.There was no statistically significant difference in the percentage of tumor shrinkage between the two groups at different time points（ P〉0.05）.No serious complications occurred during the course of treatment.Conclusion Both PLE and PVA are effective embolization agents for patients with uterine fibroids.The clinical curative effects of the two embolization agents are similar.