E抗原阳性慢性乙型肝炎患者干扰素抗病毒药物依从性的影响因素

Factors influencing compliance to interferon antiviral treatment in patients with E antigen-positive chronic hepatitis B

目的分析E抗原阳性慢性乙型肝炎(乙肝)患者干扰素抗病毒药物依从性的影响因素。方法采集E抗原阳性慢性乙肝患者318例的相关资料,回顾性分析患者干扰素抗病毒药物依从性的影响因素。结果排除干扰素不良反应不建议继续治疗或者换用核苷酸类似物86例;其余232例中,随访干扰素抗病毒依从性好组125例,依从性差组107例。依从性好组和依从性差组在性别构成比、年龄、受教育程度、医保种类、不良反应耐受和乙肝知识知晓状况等方面均有统计学差异(P<0.05)。二分类Logistic回归分析显示,男性、受教育程度高、能耐受干扰素流感样不良反应和乙肝知识知晓优良等是改善治疗依从性的独立因素(P<0.05)。结论 E抗原阳性慢性乙肝患者干扰素抗病毒药物依从性较差,加强健康教育有利于提高治疗依从性。

Objective To analyze the factors influencing compliance to interferon antiviral treatment in patients with E antigen-positive chronic hepatitis B.Methods The data related to the factors influencing compliance to interferon antiviral treatment in 318 patients with E antigen-positive chronic hepatitis B were collected and analyzed retrospectively.Results A total of 86 cases with adverse reactions to interferon antiviral treatment or substituted with nucleotide analogues was excluded.Of the rest cases,125cases（group A）were well complianced to the interferon antiviral treatment and 107cases（group B）were poorly complianced.There were significant differences in sex,age,education,insurance type,and the knowledge about hepatitis B between two groups（P〈0.05）.Binary Logistic regression analysis showed that male,well educated,well tolerance of interferon side effects and good knowledge about hepatitis B were the independent factors for good compliance（P〈0.05）.Conclusion The patients with E antigen-positive chronic hepatitis B have poor compliance to interferon antiviral treatment.The health education should be strengthened for improving the therapeutic compliance.