血清软骨寡聚基质蛋白对早期类风湿关节炎患者的诊断价值

Diagnostic value of serum cartilage oligomeric matrix protein in patients with early rheumatoid arthritis

目的探讨血清软骨寡聚基质蛋白(COMP)对早期类风湿关节炎(RA)患者的诊断价值。方法采用ELISA法检测58例早期RA患者(早期RA组)、40例晚期RA患者(晚期RA组)和40例健康体检者(正常对照组)的血清COMP浓度,分析其与关节肿胀数、压痛关节数、疾病活动指数28评分、红细胞沉降率(ESR)和血清类风湿因子、C反应蛋白(CRP)、抗环瓜氨酸肽(CCP)抗体和抗角蛋白抗体水平的相关性。结果早期RA组的血清COMP浓度高于晚期RA组和正常对照组[(22.31±9.42)μg/L vs.(18.10±10.30)μg/L和(13.69±7.33)μg/L](P<0.05)。血清COMP浓度与ESR、血清CRP和抗CCP抗体水平密切相关(P<0.05)。结论检测血清COMP浓度有助于RA患者的早期诊断。

Objective To investigate the diagnostic value of oligomeric matrix protein（COMP）in the patients with early rheumatoid arthritis（RA）.Methods Serum concentration of COMP was detected by ELISA in 58 patients with early RA（group A）,40 patients with advanced RA（group B）and 40 healthy people（group C）.The correlations of serum concentration of COMP with the number of tender joints and swelling joints,disease activity score 28 points,erythrocyte sedimetation rate（ESR）and serum levels of rheumatoid factor（RF）,C-reactive protein（CRP）,anti-cyclic citrullinated peptide（CCP）antibody,and anti-keratin antibody（AKA）were analyzed.Results Serum concentration of COMP in group A was higher than that in groups of B and C[（22.31±9.42）μg/L vs.（18.10±10.30）μg/L and（13.69±7.33）μg/L]（P〈0.05）,which was correlated closely with ESR and serum levels of CRP and anti-CCP antibody（P〈0.05）.Conclusion Detection of serum concentration of COMP is helpful in diagnosing early RA.