定量吸入气雾剂释药剂量与递送剂量的比较

Comparison of the Aerosol Dosage from the Valve and the Mouthpiece

以硫酸沙丁胺醇气雾剂和异丙托溴铵气雾剂为模型,分别采用DUSA管法和倒置溶剂的每揿主药含量测定法测定了递送剂量与释药剂量,结果递送剂量约为释药剂量的80%~85%,递送剂量更接近气雾剂实际进入体内的药量,表明采用DUSA管法更有利于控制气雾剂产品质量。

The aerosol dosages from the valve and the mouthpiece were determined in salbutamol sulphate aerosol and ipratropium bromide aerosol according to DUSA method and the method inverted in solvent （the content per actuation）. The dosage from the mouthpiece was approximately 80 %-85 % of that from the valve. The dosage from the mouthpiece was similar to the actual dose administrated to patients. The results demonstrated that the DUSA method might be more suitable for the control of the quality of aerosol products.