冠状动脉微循环功能障碍动物模型及中医药防治研究进展

Advances in animal model and traditional Chinese medicine prevention in coronary microvascular dysfunction

冠状动脉微循环功能障碍(CMD)是心脏X综合征、经皮冠状动脉介入治疗(PCI)后无复流等微循环病变的共同发病机制。随着现代影像学的迅速发展,CMD的发生和防治得到越来越多的关注。CMD动物模型是研究疾病发病机制及评价药物作用的必不可少的工具,选择合适的CMD动物模型建立方法是开展CMD实验研究首先面临的问题。临床及实验研究显示,中医药在CMD的防治方面具有一定的特色。如何进一步阐明中药作用机制寻求最佳的中西医结合治疗方案,将是中医药干预CMD的研究重点。该文将从冠状动脉微循环障碍动物模型的建立评价方法及中医药防治冠状动脉微血管环障碍的研究进展进行综述,旨为冠状动脉微循环障碍实验及中医药的实验研究提供参考。

Coronary microvascular dysfunction（CMD） is a common mechanism for some heart disease like cardiac X syndrome and no-reflow phenomenon after percutaneous coronary intervention（ PCI）. With the development of medical imageology,CMD has received increased attention. Animal model of CMD is indispensable tool for the research of pathogenesis and treatment evaluation,therefor choose an appropriate animal model is the first issue to carry out CMD research. Experimental and clinical studies have shown unique effectiveness of traditional Chinese medicine（ TCM） in CMD therapy. Clarifying of the TCM therapeutic effect mechanisms and seeking an optimal solution of combination of traditional Chinese and western medicine will be the focus of future research. This paper reviewed the establishment and evaluation of CMD animal model,as well as the intervention study of TCM on CMD. The article aims to provide reference for the basic research of CMD and the TCM experimental study on CMD.