安脑片联合喹硫平治疗谵妄叠加痴呆的多中心随机对照研究

A randomized multicenter clinical study of treatment of delirium superimposed dementia by Quetiapine and Annao Tablet

目的:观察喹硫平与安脑片治疗谵妄叠加痴呆患者的疗效。方法:将100例谵妄叠加痴呆的患者随机分为研究组与对照组,每组50例,研究组联用喹硫平与安脑片,对照组单用喹硫平。治疗前及治疗后3、6、9、12、15 d分别采用谵妄量表(DRS)、简明精神病量表(BPRS)、简易智能状态检查量表(MMSE)与日常生活能力量表(ADL)评价患者的临床疗效、认知功能与社会功能,并记录不良反应。结果:研究组脱落1例,对照组脱落3例,其余患者均完成研究。研究组患者DRS量表总分在治疗后3 d、9 d较对照组增分更多(P<0.05),治疗后6 d研究组患者DRS总分增分明显高于对照组(P<0.01);研究组患者BPRS量表总分在治疗后第3、6天明显低于对照组(P<0.01),在第9天时研究组患者BPRS总分低于对照组(P<0.05)。研究组患者的MMSE得分在治疗结束后明显高于对照组(P<0.01),研究组患者的ADL得分在治疗结束后低于对照组(P<0.05)。两组患者不良反应发生率无统计学差异(P>0.05)。结论:喹硫平联用安脑片治疗谵妄叠加痴呆起效更快,且更有利于改善患者的认知功能与社会功能。

AIM： To observe the efficacy of Quetiapine and Annao Tablet in treating delirium superimposed dementia. METHODS ： 100 dementia patients with delirium were randomly divided into the experimental group （administered with Quetiapine and Annao Tablet） and control group （administered only with Quetiapine）, 50 cases in each group. The Delirium Rating Scale （ DRS）, the Brief Psychiatric Rating Scale （BPRS）, Mini-mental State Examina- tion （MMSE） and Activity of Daily Living Scale （ADL） were evaluated before treatment and at the 3rd, 6th, 9th, 12th, 15th day after treatment, re- spectively. Adverse reactions were recorded. RE- SULTS：I case in experimental group and 3 cases in control group were dropped. The DRS scores of experimental group were higher than those of control group at the 3rd and 9th day after treatment （P 〈 0.05）, the DRS scores of experimental group were much higher than those of control group at the 6th day after treatment （P 〈 0.01 ）. The BPRS scores of experimental group were mucJa lower than those of control group at the 3rd and 6th day after treatment （ P 〈0.01 ）. The BPRS scores of experimental group were lower than those of control group at the 9th day after treatment （ P 〈 0.05 ）. The MMSE scores of experimental group were much higher than those of control group after treatment （P 〈 0.01 ）. The ADL scores of experimental group were lower than those of control group after treatment （P 〈0.05）. There＇s no statistical difference in incidence rate of adverse re- actions between the two groups （ P 〉 0.05 ）. CONCLUSION ： The combination treatment of Quetiapine and Annao Tablet had a rapid reaction to dementia patients with delirium, which also could improve the patients＇cognitive and social function.