肺癌患者化疗前后血清巨噬细胞移动抑制因子、C-反应蛋白的表达变化及意义

Changes and significance of macrophage migration inhibition factor and C-reactive protein in lung cancer patients before and after chemotherapy

目的探讨肺癌患者化疗前后血清MIF和CRP表达变化及意义。方法选取2013年6月-2015年5月杭州市肿瘤医院肿瘤内科收治的肺癌患者96例(肺癌组)、肺部良性肿瘤患者90例(良性肿瘤组);另选同期在该院体检的健康者85例作为健康对照组。分别测定健康者、良性肿瘤患者以及化疗前后肺癌患者血清MIF和CRP的浓度,比较肺癌组与其余2组、肺癌不同分期及肺癌患者化疗前后血清MIF、CRP水平差异。结果肺癌患者化疗前血清MIF和CRP水平均明显高于其余2组(P<0.05)。良性肿瘤组患者血清MIF和CRP水平均明显高于健康对照组。肺癌Ⅲ期、Ⅳ期患者血清MIF和CRP水平均显著高于肺癌Ⅰb期和Ⅱ期患者。肺癌患者化疗后1个月内血清MIF和CRP水平均较化疗前明显下降,但仍高于健康对照组,差异均有统计学意义(P<0.05)。结论血清MIF和CRP可作为肿瘤分子标志物,对肺癌的诊断、病情及预后判断具有重要的参考价值。

Objective To investigate the changes and significance of macrophage migration inhibition factor（ MIF） and C- reactive protein（ CRP） in lung cancer patients before and after chemotherapy. Methods 96 patients with lung cancer and 90 patients with benign tumors were selected from Department of Oncology of Hangzhou Tumour Hospital from June 2013 to May 2015 as the lung cancer group and the benign tumors group. And 85 healthy individuals were chosen as the healthy controls. The levels of MIF and CRP of each subject in the control group,the benign tumors group and the lung cancer group were detected before and after chemotherapy,respectively. The levels of MIF and CRP in the lung cancer group and the other two groups,the different TNM stages of lung cancer,lung cancer patients before and after chemotherapy,were compared. Results Compared with the benign tumors group and the healthy control group,the levels of MIF and CRP in the lung cancer group were significantly higher（ P〈0. 05）. Compared with the healthy control group,the levels of MIF and CRP in the benign tumors group were greatly higher. In the lung cancer group,the levels of MIF and CRP in TNM Ⅲ and TNM were greatly higher than that in stageⅠb and stage Ⅱ. The levels of MIF and CRP in the lung cancer group after 1 month＇s chemotherapy significantly decreased,but they were still higher than that in the healthy control group（ P〈0. 05）. Conclusion MIF and CRP could be the tumor markers,and they have an important significance for the diagnosis,evaluation of disease progression and prognosis in lung cancer.