MEFV基因突变与儿童过敏性紫癜遗传易感性的Meta分析

Meta-analysis of the association between MEFV gene mutations and susceptibility to children with Henoch-Schnlein purpura

目的探讨MEFV基因突变与过敏性紫癜(HSP)的相关性。方法计算机检索Pub Med、Web of Science、Medline、Cochrane Library、中国期刊全文数据库(CNKI)、万方数据库,检索从建库至2015年12月31日公开发表的关于M EFV基因突变与HSP相关性的文献,使用Rev Man 5.0软件进行Meta分析。结果最终纳入6篇英文文献,累计总病例数433例,其中MEFV基因突变136例,Meta分析结果显示合并的MEFV基因突变率为0.3(95%CI:0.23,0.37);3个亚组(关节炎组、消化道症状组、肾脏损害组)每组中MEFV基因突变与非突变比较均P>0.05,提示MEFV基因突变与临床症状无显著性差异。结论 MEFV基因突变可能是儿童HSP遗传易感因素,但在临床表现方面MEFV基因突变与非突变无明显的区别。

Objective To explore the association between MEFV gene mutations and susceptibility to Henoch-Schnlein purpura（ HSP）.Methods A comprehensive literature search of Pub Med,Web of Science,Medline,Cochrane Library,National Knowledge Infrastructure of China（ CNKI） and Wanfang Database was conducted to collect relevant studies till December 31,2015,and the extracted data were statistically analyzed by using Rev Man version 5. 0. Results A total of 433 cases from 6 English articles were enrolled in this study,in which 136 cases had MEFV gene mutations. The results of Meta-analysis showed that the pooled MEFV gene mutation rate was 0. 3（ 95%CI： 0. 23,0. 37）. In three subgroups（ arthritis group,gastrointestinal symptoms group and renal involvement group）,P value was greater than 0. 05 when comparing MEFV gene mutations adn non-mutation,which indicated that MEFV gene mutation was not significantly correlated with clinical manifestation. Conclusion MEFV gene mutation may be a susceptible factor for children with HSP. There is no difference in the clinical manifestations between patients with and without MEFV mutation.