维生素D3——非糖尿病肾病慢性肾脏病合并糖尿病的预测因子

Vitamin D3——a prognostic factor for non-diabetes chronic kidney diseases

目的:研究非糖尿病肾病慢性肾脏病(non-diabetes chronic kidney diseases,ND-CKD)3~5期患者合并糖尿病的相关因素,并用体内维生素D3水平来预测其风险。方法:对ND-CKD3~5期患者的糖尿病发生指标和维生素D3水平进行相关性分析,应用多项logistic回归分析,得出不同水平的维生素D3的ND-CKD合并糖尿病的概率值。结果:ND-CKD3~5期患者体内的维生素D3水平和餐后2 h血糖有负相关性(r=–0.430,P=2.07×10–5);该人群体内维生素D3在0~99.9,100.0~199.9,200.0~299.9 nmol/L三个水平合并糖尿病的概率分别为0.393,0.227,0.154。结论:维生素D3作为ND-CKD合并糖尿病的预测因子,有一定的临床意义。

Objective： To identify the relevant factor of non-diabetes-chronic kidney disease （ND-CKD） 3--5 phrase and apply vitamin D3 to predict its risk. Methods： A correlation analysis of vitamin D3 and parameters of diabetic occurrence were made and a logistic regression analysis was applied to work out probability value of ND-CKD in different vitamin D3 levels between occurrence indicators of patient in ND-CKD 3--S phrase and vitamin D3 level. Results： There was a negative correlation with statistically significant difference （correlation coefficient was -0.430, P=2.07x10-5） between vitamin D3 and serum glucose 2 h after oral glucose tolerance in ND-CKD patients. The rate of diabetic occurrence in ND-CKD patients with three different vitamin D3 levels （0--99.9, 100.0--199.9, 200.0--299.9 nmol/L） were estimated respectively as 0.393, 0.227 and 0.154 due to logistic analytic results. Conclusion： There is clinical significance for vitamin D3 to be a prognostic factor for ND-CKD.