20例梭形细胞癌的病理形态及免疫组织化学特征

Morphological and immunohistochemical features in 20 cases of spindle cell carcinoma

目的:探讨梭形细胞癌的形态学及免疫组织化学特征及鉴别诊断。方法:收集20例梭形细胞癌病例的临床及病理资料,分析其形态学特征及免疫表型特征。结果:20例梭形细胞癌中男性12例,女性8例,平均年龄62.5岁。肿瘤无器官特异性,肿瘤细胞呈梭形,多数病例异型性明显,少数病例细胞温和,异形性不明显。免疫组织化学示肿瘤细胞均表达vimentin;至少表达一种上皮标志物;CK,34βE12,CK5/6,EMA和P63阳性率较高;常表达desmin,calponin,SMA;不表达CD34,S100,HMB-45,myogenin,Myo D1,ALK。结论:梭形细胞癌是一种具有独特形态学和免疫表型的肿瘤。

Objective： To investigate the morphological and immunohistochemical features and differential diagnosis of spindle cell carcinoma. Methods： The clinical and pathological data of 20 cases of spindle cell carcinoma were collected, and the morphological characteristics and immunohistochemical features were analyzed. Results： Among the 20 cases of spindle cell carcinoma, 12 were male and 8 were female. The mean age was 62.5 years. Tumor cells were fusiform while tumor was not organ specificity, most cases were pleomorphism which is not obvious, a few mild cases of cells. Immunohistochemistry revealed that vimentin was positive in all cases, at least one of epithelial markers was positive.CK,34βE12,CK5/6,EMA and p63 had higher positive rate. And desmin, calponin, SMA were positive in many cases. CD34, S-100, HMB-45, myogenin, MyoD1, ALK were negative in all cases. Conclusion： Spindle cell carcinoma is a kind of tumor with special morphology and immune phenotype.