白细胞过滤对输血反应的临床意义研究

Research on clinical significance of white cell filtration for blood transfusion reaction

目的研究白细胞过滤对输血反应的临床意义。方法 2014年1月~2016年1月收治的220例输血治疗患者为研究对象,根据患者入院时间的不同,以2015年1月为划分点,此前入院的纳入对照组(给予未过滤白细胞的血浆),此后入院的纳入研究组(给予过滤白细胞的血浆),各110例。对比两组患者的输血反应。结果研究组的非溶血性发热性输血反应(FNHTR)发生率为8.18%,低于对照组的30.00%,差异有统计学意义(P<0.05)。输血后,研究组的体温升高幅度为(0.43±0.04)℃,低于对照组的(1.36±0.53)℃,差异具有统计学意义(P<0.05)。研究组患者总蛋白(TP)、凝血酶原时间(PT)、血浆纤维蛋白原(FIB)、凝血因子Ⅴ活性(FⅤ:C)及凝血因子Ⅷ活性(FⅧ:C)均优于对照组,差异均有统计学意义(t=2.719、9.535、9.381、3.817、8.040,P<0.05)。结论白细胞过滤避免了输血反应的出现,提高了输血治疗安全性与有效性,值得推广。

Objective To research clinical significance of white cell filtration for blood transfusion reaction. Methods A total of 220 patients with blood transfusion treatment received from January 2014 to January 2016 as study subjects,and January 2015 as divide point, patients received before January 2015 as control group（received plasma without white cell filtration）, and received after January 2015 as research group（received plasma with white cell filtration）, with 110 cases in each group. Blood transfusion reaction was compared in two groups. Results The research group had lower incidence of febrile non-haemolytic transfusion reaction（FNHTR） as 8.18% than 30.00% in the control group,and the difference had statistical significance（P〈0.05）. After blood transfusion, the research group had lower temperature rise extent as（0.43±0.04）℃ than（1.36±0.53）℃ in the control group,and the difference had statistical significance（P〈0.05）. The research group had better total protein（TP）, prothrombin time（PT）, plasma fibrinogen（FIB）, blood coagulation factor Ⅴ activity（FⅤ ： C） and blood coagulation factor Ⅷ activity（FⅧ ： C） than the control group, and differences had statistical significance（t=2.719, 9.535, 9.381, 3.817, 8.040, P〈0.05）. Conclusion White cell filtration can avoid occurrence of blood transfusion reactions and improved security and efficiency of blood transfusion treatment. This method is worth promotion.