思密达治疗小儿腹泻的临床疗效研究

Research of clinical effect by Smecta in the treatment of infantile diarrhea

目的研究蒙脱石散(思密达)治疗小儿腹泻的临床疗效。方法 102例腹泻患儿按照随机数字表法分为A组与B组,每组51例。A组患儿采用思密达治疗,B组患儿采用双歧杆菌乳杆菌三联活菌片(金双歧)治疗,比较两组患儿的临床治疗总有效率、腹泻停止时间以及住院时间。结果 A组痊愈38例、好转12例、无效1例,临床治疗总有效率为98.04%;B组痊愈24例、好转19例、无效8例,临床治疗总有效率为84.31%;A组患儿的临床治疗总有效率显著高于B组,差异具有统计学意义(χ2=5.97,P<0.05)。A组患儿平均腹泻停止时间为(2.42±0.42)d,平均住院时间为(4.32±0.11)d;B组患儿平均腹泻停止时间为(4.67±1.45)d,平均住院时间为(5.62±1.32)d;A组患儿腹泻停止时间、住院时间均明显短于B组,差异具有统计学意义(P<0.05)。结论思密达治疗小儿腹泻的临床疗效比较突出,患儿的临床治疗总有效率相对较高,腹泻停止时间与住院时间较短,有助于改善患儿的生活质量,快速发挥药物治疗的价值。

Objective To research clinical effect by montmorillonite powder（Smecta） in the treatment of infantile diarrhea. Methods A total of 102 children with infantile diarrhea were divided by random number table into group A and group B, with 51 cases in each group. Group A received Smecta for treatment, and group B received bifidobacterium lactobacillus triple viable tablets（golden bifidobacterium） for treatment. Comparison was made on total effective rate of clinical treatment, diarrhea stop time and hospital stay time between the two groups. Results Group A had 38 cured cases, 12 improved cases and 1 ineffective case, with total effective rate of clinical treatment as 98.04%. Group B had 24 cured cases, 19 improved cases and 8 ineffective cases, with total effective rate of clinical treatment as 84.31%. Group A had obviously higher total effective rate of clinical treatment than group B, and the difference had statistical significance（χ^2=5.97, P〈0.05）. Group A had mean diarrhea stop time as（2.42±0.42） d and mean hospital stay time as（4.32±0.11） d. Group B had mean diarrhea stop time as（4.67±1.45） d and mean hospital stay time as（5.62±1.32） d. Group A had much shorter diarrhea stop time and hospital stay time than group B, and their difference had statistical significance（P〈0.05）. Conclusion Smecta shows excellent clinical effect in treating infantile diarrhea, along with high total effective rate of clinical treatment and short diarrhea stop time and hospital stay time. This method is helpful to improve quality of life in children, and to quickly reveal therapeutic value by drug.