乳腺癌病人内分泌治疗的副反应对生命质量的影响

Influence of adverse reactions of endocrine therapy on quality of life of patients with breast cancer

[目的]探讨影响乳腺癌内分泌治疗病人生命质量的相关因素。[方法]采用内分泌治疗调查问卷和乳腺癌病人生命质量测定量表中文版(FACT-B)对沈阳市某三级甲等医院乳腺癌术后接受内分泌治疗第1年的237例病人进行调查,分析影响乳腺癌内分泌治疗病人生命质量的相关因素。[结果]216例(91.14%)病人出现了不同程度的药物不良反应;FACT-B量表评分为(97.860±19.353)分,处于中等水平;关节/肌肉疼痛、阴道流血、阴道干燥、食欲不振/恶心呕吐对乳腺癌病人生命质量有影响。[结论]乳腺癌病人内分泌治疗的药物副反应发生率高,乳腺专科医护人员或内分泌治疗咨询师应持续关注病人的情况,加强指导,给予药物或非药物干预,解除病人对服药的顾虑,改善乳腺癌内分泌治疗病人服药期间的生命质量。

Objective To probe into the related factors affecting the quality of life of breast cancer patients with endocrine therapy. Methods： A total of 237 breast cancer patients receiving endocrine therapy in the first year in a third grade A hospital in Shenyang city were investigated by using measurement scale of Chinese version of the quality of life questionnaire FACT -B and endocrine therapy of breast cancer patients,analyze the influence factors of the quality of life of breast cancer patients with endocrine treatment. Results： 216 cases of patients（91. 14%） experienced adverse drug reactions in different degree; FACT - B score（97. 860 ± 19. 353） at the middle level; joint/muscle pain, vaginal bleeding, vaginal dryness, loss of appetite and nausea and vomiting had impact for the quality of life of patients with breast cancer. Conclusions： The incidence of drug side effects of endocrine therapy in breast cancer patients was higher, breast specialist medical staff and endocrine therapy consultant should continue to focus on the patient＇s condition, strengthen the guidance,give the drug or non drug intervention,relieve the patients’ concerns on medication, improve the quality of life of patients with breast cancer during taking durgs in endocrine therapy.