氟伐他汀联合阿司匹林对糖尿病性下肢动脉硬化闭塞症患者相关指标的影响

Effects of Fluvastatin Combined with Aspirin on the Related Indicators of Patients with Diabetic Lower Extremity Arteriosclerosis Occlusive Desease

目的:探讨氟伐他汀联合阿司匹林对糖尿病性下肢动脉硬化闭塞症(LEAOD)患者相关指标的影响。方法:80例糖尿病性LEAOD患者随机分为对照组(40例)和观察组(40例)。在常规治疗基础上,对照组患者每晚口服瑞舒伐他汀钙片5 mg+阿司匹林肠溶片100 mg;观察组患者每晚口服氟伐他汀钠胶囊40 mg+阿司匹林肠溶片100 mg。两组疗程均为3个月。观察两组患者治疗前后纤维蛋白原、血浆D-二聚体、血液黏度、总胆固醇(TC)、三酰甘油(TG)、糖化血红蛋白(Hb A1c)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、颈动脉内膜厚度及TC、TG、Hb A1c、LDL-C、HDL-C达标情况、颈动脉内膜增厚、斑块形成、狭窄及闭塞患者例数,并记录不良反应发生情况。结果:治疗后,两组患者纤维蛋白原、血浆D-二聚体、血液黏度、TC、TG、Hb A1c、LDL-C、颈动脉内膜厚度均显著低于同组治疗前,且观察组显著低于对照组;两组患者HDL-C水平均显著高于同组治疗前,且观察组显著高于对照组,差异均有统计学意义(P<0.05)。观察组患者TC、TG、LDL-C、HDL-C达标率均显著高于对照组,颈动脉内膜增厚、斑块形成患者占比均显著少于对照组,差异均有统计学意义(P<0.05);两组患者Hb A1c达标率、颈动脉狭窄及闭塞患者占比、不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:氟伐他汀联合阿司匹林用于糖尿病性LEAOD,可显著改善患者血液黏度、血脂和血管内皮功能,减少血栓疾病的发生风险,且未增加不良反应的发生。

OBJECTIVE：To investigate the effects of fluvastatin combined with aspirin on the related indicators of patients with diabetic lower extremity arteriosclerosis occlusive desease（LEAOD）. METHODS：80 patients with diabetic LEAOD were randomly divided into control group（40 cases）and observation group（40 cases）. Based on convertional treatment,control group was given Rosuvastatin calcium tablet 5 mg＋Aspirin enteric-coated tablet 100 mg every evening;observation group was given Fluvastatin sodium capsule 40 mg ＋ Aspirin enteric-coated tablet 100 mg. They were treated for 3 months. Fibrinogen,plasma D-dimer,blood viscosity,cholesterol（TC）,triglyceride（TG）,glycosylated hemoglobin（Hb Alc）,low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HDL-C）,carotid intima-media thickness,compliance situation of TC,TG,Hb Alc,LDL-C and HDL-C,cases of carotid intima thickening,plaque formation,stenosis and occlusion before and after treatment were observed,and the incidence of adverse reactions was recorded. RESULTS：After treatment,fibrinogen,plasma D-dimer,blood viscosity,TC,TG,Hb Alc,LDL-C and carotid intima-media thickness in 2 groups were significantly lower than before treatment,and observation group was significantly lower than control group;HDL-C in 2 groups was significantly higher than before,and observation group was significantly higher than control group,with statistical significance（P〈0.05）. Compliance rates of TC,TG,LDL-C and HDL-C in observation group were significantly higher than control group,proportion of carotid intimathickening and carotid plaque formation were significantly less than control group,with statistical significance（P〈0.05）,there were no significant differences in the compliance rate of Hb A1 c,proportion of carotid stenosis and occlusion and the incidence of adverse reactions in 2 groups（P〉0.05）. CONCLUSIONS ：Fluvastatin combined with aspirin can significantly improve the patients ＇blood viscosity,blood lipid,vascular endothelial function in the treatment of diabetic LEAOD,it can reduce the thrombotic disease risk,and does not increase the incidence of adverse reactions.