期刊文献+

补肾健脾法治疗原发性骨质疏松症的Meta分析 被引量:20

Meta-analysis of Reinforcing Kidney and Invigorating Spleen Principle in the Treatment of Primary Osteoporosis
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摘要 目的:系统评价补肾健脾法治疗原发性骨质疏松症(POP)的疗效,为临床提供循证参考。方法:计算机检索中文科技期刊数据库、万方数据库、中国期刊全文数据库、Medline、Pub Med、Elsevier、Springer、Web of Science、Ovid,纳入补肾健脾法(试验组)对比其他方式(非补肾健脾法,对照组)治疗POP的临床随机对照试验(RCT),提取资料并运用改良Jadad评分量表进行质量评估后,采用国际Cochrane协作网提供的Rev Man 5.3统计软件进行Meta分析。结果:共纳入28项RCT,合计2 849例患者。Meta分析结果显示,试验组患者总有效率[OR=3.80,95%CI(2.76,5.23),P<0.001]、血清骨钙素水平[MD=2.23,95%CI(1.80,2.66),P<0.001]、股骨颈骨密度(BMD)[MD=0.04,95%CI(0.00,0.08),P=0.05]、腰椎BMD[MD=0.07,95%CI(0.03,0.11),P=0.001]显著高于对照组,血清碱性磷酸酶[MD=-5.59,95%CI(-10.51,-0.66),P=0.03]、视觉模拟疼痛评分[MD=-1.38,95%CI(-1.87,-0.89),P<0.001]显著低于对照组,差异均有统计学意义。两组患者尿钙肌酐比值[MD=-0.07,95%CI(-0.17,0.02),P=0.12]和血清Ca^(2+)水平[MD=0.16,95%CI(-0.07,0.39),P=0.17]比较,差异无统计学意义。结论:补肾健脾法治疗POP疗效较好,可以改善患者骨代谢过程中的成骨过程,降低破骨过程的活跃性,缓解患者的疼痛。 OBJECTIVE:To systematically review the efficacy and safety of reinforcing kidney and invigorating spleen principle in the treatment of primary osteoporosis(POP)in middle and elderly aged patients,and provide evidence-based reference for clinic. METHODS:Retrieved from VIP,Wanfang Database,CJFD,Medline,Pub Med,Elsevier,Springer,Web of Science and Ovid,randomized control trials(RCT)about reinforcing kidney and invigorating spleen principle(test group)versus other methods(no reinforcing kidney and invigorating spleen principle,control group)in the treatment of POP were collected. Meta-analysis was performed by using Rev Man 5.3 software provided by Cochrane after data extraction and quality evaluation modified by Jadad scale. RESULTS:Totally 28 RCTs were enrolled,involving 2 849 patients. Results of Meta-analysis showed,the total effective rate [OR=3.80,95% CI(2.76,5.23),P〈0.001],BGP level [MD=2.23,95% CI(1.80,2.66),P〈0.001],BMD level of femoral neck [MD=0.04,95%CI(0.00,0.08),P=0.05] and BMD level of lumbar spine [MD=0.07,95%CI(0.03,0.11),P=0.001] in test group were significantly higher than control group,ALP level [MD=-5.59,95% CI(-10.51,-0.66),P=0.03] and VAS score[MD=-1.38,95%CI(-1.87,-0.89),P〈0.001] were significantly lower than control group,with statistical significance. There were no significant differences in U-Ca/Cr [MD=-0.07,95%CI(-0.17,0.02),P=0.12] and serum Ca^(2+)level [MD=0.16,95%CI(-0.07,0.39),P=0.17] in 2 groups. CONCLUSIONS:Reinforcing kidney and invigorating spleen principle can improve patients' osteogenesis during bone metabolism,reduce the activity of the osteoclastic process and relief patients' pain in the treatment of POP.
出处 《中国药房》 CAS 北大核心 2017年第6期795-799,共5页 China Pharmacy
关键词 补肾健脾法 中老年 原发性骨质疏松症 META分析 疗效 Reinforcing kidney and invigorating spleen principle Middle and elderly aged Primary osteoporosis Meta-analysis Efficacy
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