酒依赖患者认知功能障碍的临床观察

Cognitive Impairment in Patients with Alcohol Dependence

目的:探讨画钟试验(CDT)、蒙特利尔认知评估量表(Mo CA)在评价酒依赖患者认知功能障碍中的作用。方法:选取48例酒依赖患者为病例组,另外选取50例与病例组相匹配的正常人为对照组,两组分别运用画钟试验(CDT)、蒙特利尔认知评估量表(Mo CA)进行评估。结果:酒依赖组的CDT分值显著低于对照组。酒依赖组的Mo CA总分及视空间执行、注意、计算、概括抽象、记忆评分均显著低于对照组。酒依赖组持续饮酒时间与CDT分值、MoCA总分、视空间执行、概括抽象、记忆评分呈负相关;酒依赖组日饮酒量折合纯酒精量与CDT分值、MoCA总分、视空间执行、概括抽象评分呈负相关。结论:酒依赖患者存在认知功能损害,且持续饮酒时间及日饮酒量与认知功能损害严重程度有关。

Objective： To assess the cognitive impairment induced by alcohol dependence with clock drawing test （CDT） and Montreal cognitive assessment（MoCA）. Methods： Forty-eight patients with alcohol dependence and fifty matched healthy controls underwent CDT and MoCA scale inspection. Results： CDT scores of alcoholic subjects were sig- nificantly lower than those of control group. MoCA total scores and executive functions, attention, calculation, abstraction, recall scores of alcoholic subjects were significantly lower than those of control group. The drinking duration was negatively correlated with CDT scores, MoCA total scores, executive functions scores, abstraction scores and recall scores. The alcohol consumption distribution in grams per day of pure alcohol was negatively correlated with CDT scores, MoCA total scores, executive functions scores and abstraction scores. Conclusion： Patients with alcohol dependence suffer cognitive impairment and the severity of cognitive impairment is correlated with the drinking duration and alcohol consumption distribution in grams per day of pure alcohol.