不同剂量重组人干扰素α1b雾化吸入治疗毛细支气管炎的疗效及不良反应分析

Efficacy and adverse effects of different doses of recombinant human interferon alpha 1b in the treatment of bronchiolitis

目的研究不同剂量重组人干扰素α1b雾化吸入治疗毛细支气管炎的疗效及安全性。方法选取2016年1月—2016年9月期间我院儿科收治的年龄≤2 a的毛细支气管炎患儿86例,均符合毛细支气管炎诊断标准,随机分为观察一组(29例)、观察二组(29例)和对照组(28例)。所有患儿均给予综合常规治疗,观察一组患儿雾化吸入生理盐水+质量浓度为0.2 g/L的沙丁胺醇+1μg/(kg·次)重组人干扰素α1b,观察二组患儿雾化吸入生理盐水+质量浓度为0.2 g/L的沙丁胺醇+2μg/(kg·次)重组人干扰素α1b。比较三组患儿治疗有效率、临床症状改善和不良反应发生情况。结果观察一组与观察二组在治愈率和总有效率两个方面均显著高于对照组(P<0.05),但观察一组与观察二组治愈率和总有效率比较差异不显著(P>0.05);观察一组和观察二组患儿临床症状和体征持续时间明显少于对照组(P<0.05),但观察一组和观察二组患儿临床症状和体征持续时间无显著差异(P>0.05);三组患儿不良反应发生率差异不显著(P>0.05)。结论低剂量与高剂量雾化吸入重组干扰素α1b对于小儿毛细支气管炎临床疗效接近,且均无严重不良反应,综合经济效益和社会效益考虑,在临床上推广低剂量雾化吸入重组干扰素α1b治疗小儿毛细支气管炎更具价值。

Objective To study the effects of different doses of recombinant human interferon α1b inhalation efficacy and safety in the treatment of bronchiolitis. Methods 86 cases of children,who were less than 2 years old were selected in department of pediatrics from January 2016 to September 2016. They were randomly divided into for observation group Ⅰ（29 cases）,observation group Ⅱ（29 cases） and control group（28 cases）. All the patients were treated with conventional therapy. Group Ⅰ with atomization inhalation of salbutamol and 0. 02% with saline ＋ 1 μg/kg times of recombinant human interferon α1b were observed and the same as in the two groups Ⅱ with atomization inhalation of salbutamol and 0. 02% with saline ＋ 2 μg/kg recombinant human interferon α1b. The treatment efficiency,the improvement of clinical symptoms and adverse reactions were compared. Results The cure rate and total effective rate of observation group Ⅰand Ⅱ were significantly higher than those in the control group（P〈0. 05）,there were no significant differences in the cure rate and total effective rate between observation group Ⅰand Ⅱ（P〈0. 05）. The clinical symptoms and signs of the patients of observation groupⅠand Ⅱ were significantly higher than those in the control group（P〉0. 05）,there were no significant differences in the clinical symptoms and signs of the patients between observation group Ⅰand Ⅱ（P〉0. 05）. There was no significant difference in the incidence of adverse reactions between the three groups（P〉0. 05）. Conclusion There were no serious adverse reactions in low dose and high dose of atomization inhalation of recombinant interferon α1b for close to the clinical curative effect of children with bronchiolitis. Considering comprehensively economic benefits and social benefits,it is worth of promotion low dose of atomization inhalation of recombinant interferon 1b in the treatment of children with bronchiolitis.