双柏散与喜疗妥软膏治疗PICC相关性静脉炎的临床疗效对比

Comparision of clinical efficacy in the treatment of phlebitis correlation with peripherally inserted central catheter(PICC) between Shuangbai Powder and Hirudoid cream

目的探讨双柏散与喜疗妥软膏治疗经外周静脉穿刺置入中心静脉导管(PICC)相关性静脉炎的临床疗效对比。方法选取PICC相关性静脉炎患者80例,随机分为观察组和对照组各40例,观察组采用双柏散水蜜制剂外敷,对照组采用喜疗妥软膏外涂,观察2组临床疗效。结果观察组显效率87.5%,总有效率97.5%;对照组显效率65%,总有效率80%。观察组显效率和总有效率均高于对照组(P<0.05)。两组在治疗后各时点疼痛评分均低于治疗前(P<0.01);对照组在治疗24h后各治疗时点疼痛评分均低于治疗前,差异有显著性意义(P<0.01),但在12 h治疗时点疼痛评分虽亦低于治疗前,但差异无显著性意义(P>0.05)。观察组患者在治疗后12 h、24 h、36 h和48 h时点的静脉炎疼痛评分均低于对照组,差异有显著性意义(P<0.01或P<0.05),而在72 h时点两组疼痛评分差异无显著性意义(P>0.05)。结论本研究结果表明双柏散外敷治疗PICC相关性静脉炎效果优于喜疗妥组,且疼痛症状改善时间更早。

Objective To compare clinical efficacy in the treatment of phlebitis correlation with peripherally inserted central catheter（PICC） between Shuangbai Powder and Hirudoid cream. Methods 80 patients with PICC correlation phlebitis were randomly divided into observation group and control group. There were 40 cases in the observation group treated with Shuangbai Powder and 40 cases in the control group treated with Hirudoid cream. We observed clinical curative effect of two groups. Results The efficiency rate was 87. 5% and total effective rate was 97. 5% in the observation group. The efficiency rate was 65% and total effective rate was 80% in the control group. The difference of the efficiency rate and total effective rate between observation group and control group was significance（P〈0. 05）. The pain scores were lower in observation group after treatment than it was before（P〈0. 01）; The pain scores were lower in control group after 24 hours treatment than it was before（P〈0. 01）; The pain scores after 12 hours of treatment lower than before,but there was no significant difference（P〈0. 05）. The pain scores after 12 hours,24 hours,36 hours and 48 hours of treatment in observation group were lower than control group（P〈0. 01 or P〈0. 05）,but there was no significant difference in the pain score of both groups after 72 hours of treatment（P〈0. 05）. Conclusion The clinical efficacy in the treatment of phlebitis correlation with peripherally inserted central catheter（PICC） by Shuangbai Powder is better than Hirudoid cream,and the time of pain relief in the group treated by Shuangbai Power is earlier than it treated by Hirudoid cream.