微球体培养富集肿瘤干细胞及其潜在的临床应用

Micro-sphere culture gathers cancer stem cell and its potential clinical application

肿瘤干细胞假说是近年来提出的关于肿瘤的新理论,该理论认为肿瘤干细胞在肿瘤发生、发展和转移等过程中起着决定性的作用,肿瘤干细胞理论的提出给肿瘤治疗提供了新的思路和策略。但是,肿瘤中只有一小部分细胞为肿瘤干细胞,因此鉴定并富集这些细胞以进一步研究是众多科研人员面临的巨大挑战。微球体培养技术是近年发展起来的一种有效富集肿瘤干细胞的技术,该技术的应用使肿瘤干细胞的研究变得更加容易,并使临床应用这些细胞来评价肿瘤进展及患者预后成为可能,本文将对该技术及其与微系统的整合进行详细的阐述。

Cancer stem cell hypothesis has become a new theory. According to this theory, cancer stem cells play a decisive role in carcinogenesis, progression, and metastasis. This theory offered new ideas and strategies for cancer treatment. However, only a small fraction of cells in a tumor were cancer stem cells. Therefore, the identification and enrichment of these cells are significant challenges for numerous researchers conducting further study. Micro-sphere culture has been an effective tumor stem cell enrichment technology in recent years. The application of this technique makes the cancer stem cell research process easy. In addition, it makes the evaluation of tumor progression and prognosis of patients in clinical possible. This article will focus on the applications of this technology, and microsystem integration will be described in detail.