除草剂草甘膦研究进展

Research Progress of Herbicide Glyphosate

除草剂草甘膦在农业、林业以及人们的日常生活中发挥着至关重要的作用。它主要通过对5-烯醇式丙酮酸莽草酸-3-磷酸合成酶(EPSP)的抑制,阻碍芳香氨基酸的生物合成,从而达到去除杂草的目的。早前的毒性试验表明,草甘膦对非靶标生物存在着相关的生物毒性,使得人们对草甘膦是否影响人类健康的关注度不断增加。通过查阅相关文献,总结了草甘膦以及目前应用最广的商品化除草剂Roundup对生物体的影响。分析了草甘膦对动植物产生危害的机理,为今后研究草甘膦的基因毒性和致癌性提供依据。

Herbicides glyphosate plays a vital role in agriculture, forestry and people＇s daily life. It aims to clear weeds by in- hibiting 5-enolpyruvyl-shikimate-3-phosphate, which can impede biosynthesis of aromatic amino acid. Earlier toxicity tests showed that glyphosate had related biological toxicity to non target organisms. So people＇s concern about impact of glyphosate on human health had increased. Effects of glyphosate and Roundup which is the most widely used commercial herbicide nowadays on organism were summarized by consulting relevant literature. Mechanism of glyphosate toxicity to plants and animals was ana- lyzed, which provided basis for research on gene toxicity and carcinogenic effects of glyphosate in the future.