高敏C反应蛋白在不同类型冠心病中的检测及临床意义

Clinical significance of determination high-sensitivity C-reactive protein in different types of coronary heart disease

目的探讨不同类型冠心病（coronary heart disease，CHD）患者高敏C反应蛋白（high sensitive C—reactive protein，hs-CRP）的检测结果，并分析其临床意义。方法选择2014年11月～2015年11月于本院就诊的稳定型心绞痛（stable angina pectoris，SAP）患者、不稳定型心绞痛（unstable angina pectoris，UAP）患者及急性心肌梗死（acute myocardial infarction，AMI）患者各40例，同期选择于本院进行体检的40例健康受试者为对照组，检测四组的hs—CRP水平，并比较分析四组检测结果的差异。结果对照组的hs-CRP水平最低，与其他三组比较存在显著差异；其他三组hs-CRP水平由高到低分别为：AMI组〉UAP组〉SAP组，差异有统计学意义（P〈0．05）。结论冠心病发作时血液中hs-CRP含量升高，病情越重则hs-CRP含量越高，临床可应用hs-CRP检测结果来判断冠心病的类型。

Objective To explore the different measurement results of high sensitive C-reactive protein（hs-CRP） in patients with different types of coronary heart disease（CHD）, and to analyze the clinical significance. Methods Each 40 cases of patients with stable angina pectoris （SAP）, unstable angina pectoris（UAP） and acute myocardial infarction （AMI）were enrolled in our hospital from November 2014 to November 2015.40 healthy subjects were selected as control group from the same hospital in corresponding period. The levels of hs-CRP in the four groups were measured, and the differences were compared among the four groups. Results The hs-CRP level of the control group was the lowest, which was significantly different from those of the other three groups. The hs-CRP level of other three groups from high to low： AMI group〉UAP group〉SAP group （P〈0.05）. Conclusion Hs-CRP increase in the blood of patients with coronary heart disease, the more severe has the higher determination results of hs-CRP, the types of patients with coronary heart disease can be judged by determination results of hs-CRP in clinical.