艾司西酞普与非洛地平联合治疗高血压合并抑郁的效果观察

Observation of the efficacy of escitalopine combined with felodipine in the treatment of hypertension complicated with depression

目的 探讨艾司西酞普与非洛地平联合治疗高血压合并抑郁的效果。方法 选取2014年2月-2015年5月在我院诊治的高血压合并抑郁症的患者98例,根据随机奇偶数字法分为研究组和对照组,各49例,对照组给予降压药物非洛地平缓释片（5 mg/d）,研究组在对照组的基础上,给予抗抑郁药物艾司西酞普兰（10 mg/d）,治疗4周后分别对两组患者的临床基线数据、治疗前后的舒张压、收缩压、汉密尔顿抑郁量表和汉密尔顿焦虑量表进行比较和分析,并比较治疗过程中的不良反应。结果 研究组与对照组的临床基线数据相比较,差异无统计学意义（P〉0.05）;两组患者治疗前舒张压、收缩压、汉密尔顿抑郁量表和汉密尔顿焦虑量表评分比较,差异无统计学意义（P〉0.05）,治疗后两组患者的舒张压、收缩压、汉密尔顿抑郁量表和汉密尔顿焦虑量表均显著降低,且研究组与对照组比较,差异具有统计学意义（P〈0.05）;两组患者治疗期间的不良反应发生率比较,差异无统计学意义（P〉0.05）。结论 艾司西酞普兰与非洛地平联合治疗高血压合并抑郁患者的临床效果较好且安全性高,临床上应予以推广。

Objective To investigate the effect of escitalopram combined with felodipine in the treatment of hypertension complicated with depression. Methods A total of 98 patients with hypertension complicated with depression who were diagnosed and treated in our hospital from February 2014 to May 2015 were selected. According to the random odd and even number, they were divided into the study group and the control group, with 49 cases in each group. The control group was treated with antihypertensive drug of felodipine（5 mg/d）. The study group was given antidepressant drug of escitalopram（10 mg/d） on the basis of the control group. The clinical baseline data, diastolic blood pressure, systolic blood pressure, hamilton depression scale（HAMD） and hamilton anxiety scale（HAMA） before and after the treatment were compared between the two groups after treatment for 4 weeks. The adverse events were also compared during the course of treatment. Results There was no significant difference in the clinical baseline data between the study group and the control group（P〉0.05）; there were no significant differences between the two groups in diastolic blood pressure, systolic blood pressure, hamilton depression scale and hamilton anxiety scale before the treatment（P〉 0.05）. After the treatment, the diastolic blood pressure, systolic blood pressure, hamilton depression scale and hamilton anxiety scale of the two groups were significantly reduced, and the differences between the study group and the control group were statistically significant（P〈0.05）; there was no significant difference in adverse events between the two groups during the course of treatment（P〉0.05）. Conclusion Escitalopram combined with felodipine in the treatment of hypertension complicated with depression has a better clinical efficacy and high safety, which should be promoted and applied clinically.