摘要妊娠期肝内胆汁淤积（intrahepatic cholestasis of pregnancy,ICP）是妊娠期肝内特有的一种疾病,以皮肤瘙痒和轻度肝功能异常为主要特征[1-4]。ICP是一种可逆的胆汁淤积,主要出现在第2次或者第3次妊娠的第3个月,并且皮肤瘙痒和肝功能轻度异常在产后迅速消失,产妇预后通常都很好[3,5]。
4Reyes H. The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy[J].Gastroenterology Clinics of North America,1992,(04):905-921.
5Jiang ZH,Qiu ZD,Liu WW. IntraHepatic cholestasis of pregnancy and its complications.Analysis of 100 cases in Chongqing area[J].Chinese Medical Journal(Engl),1986,(12):957-960.
6Kroumpouzos G. Intrahepatic cholestasis of pregnancy:what' s new[J].Journal of the European Academy of Dermatology and Venereology,2002,(04):316-318.
7Bukovsky A,Cekanova M,Caudle MR. Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol[J].Reproductive Biology and Endocrinology,2003.1-13.
8Mansur Ade P,Nogueira CC,Strunz CM. Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease[J].Archives of Medical Research,2005,(05):511-517.
9曹泽毅.中华妇产科学[M]北京:人民卫生出版社,2001.
10Almeida S,Franken N,Zandoná MR. Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status[J].Pharmacogenomics,2005,(01):30-34.
8Expert Committee on the 2015 update of expert consensus on the diagnosis and treatment of cholestatic liver disease.胆汁淤积性肝病诊断治疗专家共识:2015年更新[J].临床肝胆病杂志,2015,31(10):1563-1574. 被引量：63
