依达拉奉对颅内肿瘤γ-刀术后脑水肿的治疗作用及对血清肿瘤坏死因子-α水平的影响分析

Analysis of therapeutic effects and serum TNF-αlevels effects of edaravone on cerebral edema after gamma knife treatment of intracranial tumor

目的探讨依达拉奉对颅内肿瘤γ-刀术后脑水肿的治疗作用及对血清肿瘤坏死因子-α(TNF-α)水平的影响。方法 2014年2月至2016年1月选择该院诊治的颅内肿瘤γ-刀术后脑水肿患者98例,根据入院顺序分为观察组与对照组,各49例,对照组选择盐酸丁咯地尔注射液治疗,观察组使用依达拉奉注射液治疗,2组患者都给予常规基础治疗,均观察14d。结果治疗后观察组患者总有效率为98.0%,对照组为79.6%,差异有统计学意义(P<0.05)。观察组与对照组治疗后的血清TNF-α水平分别为(113.92±23.81)和(289.49±42.10)ng/L,均低于治疗前的(882.94±30.81)和(879.13±41.92)ng/L(P<0.05),观察组低于对照组(P<0.05)。2组患者治疗后的脑水肿面积与治疗前比较,明显减少(P<0.05),且观察组治疗后的脑水肿面积少于对照组(P<0.05)。观察组与对照组治疗前Glasgow预后(GCS)评分分别为(7.23±0.45)分和(7.19±0.67)分,治疗后分别为(13.87±1.11)分和(10.48±1.49)分,均高于治疗前(P<0.05),观察组高于对照组(P<0.05)。结论依达拉奉在颅内肿瘤γ-刀术后脑水肿治疗的应用能有效降低炎性反应,减轻脑水肿,提高GCS评分,有利于综合疗效的改善,具有较好的临床应用价值。

Objective To investigate the therapeutic effects and serum TNF-αlevels effects of edaravone on cerebral edema after gamma knife treatment of intracranial tumor.Methods Used a prospective study method,98 cases of No.309 hospital of PLA for diagnosis and treatment of intracranial tumor gamma-knife radiosurgery of brain edema patients were selected from February 2014 to January 2016,accorded to admission order were equally divided into observation group and control group,each group were 49 cases,the control group were given the ranitidine hydrochloride Buflomedil injection in the treatment,the observation group were given the edaravone injection in the treatment,two groups were given conventional treatment,the treatment observation times were14 d.Results The total effective rate of the observation group was 98.0%,and the control group was 79.6%.The total effective rate of the observation group was significantly higher than that of the control group（P〈0.05）.The serum TNF-αlevels after the treatment were（113.92±23.81）and（289.49±42.10）ng/L that were significantly lower than before treatment of（882.94±30.81）and（879.13±41.92）ng/L（P〈0.05）,the observation group was significantly lower than the control group（P〈0.05）.The area of cerebral edema in the observation group and control group after treatment were significantly reduced（P〈0.05）,and the observation group was significantly less than the control group after treatment（P〈0.05）.The GCS scores in the observation group and the control group before treatment were（7.23±0.45）points and（7.19±0.67）points,after treatment were（13.87±1.11）points and（10.48±1.49）points that were significantly higher than that before treatment（P〈0.05）,while the observation group was significantly higher than that of the control group（P〈0.05）.Conclusion The application of edaravone in the treatment of intracranial tumor gamma knife radiosurgery of brain edema can effectively reduce inflammation,alleviate brain edema and improve the GCS score,it′s conducive to the improvement of comprehensive effect and has very good application values.