小儿川崎病应用丙种球蛋白治疗的效果评估及最佳剂量研究

Effects evaluation and optimal dose study of gamma globulin in treatment of Kawasaki disease

目的探讨丙种球蛋白治疗小儿川崎病的临床效果和最佳剂量。方法选择2010年8月至2015年8月该院收治的川崎病患儿108例,根据入院编号的偶数和奇数将其分为2组,对照组患者采用常规剂量丙种球蛋白治疗,观察组患者运用大剂量丙种球蛋白治疗。比较2组的治疗效果、临床症状消失时间及不良反应发生率。结果与对照组比较,观察组患者治疗总有效率明显增高,差异有统计学意义(P<0.05);2组患者的黏膜充血、皮疹、手足症状及淋巴结肿大消失时间比较,差异有统计学意义(P<0.05);与对照组比较,观察组不良反应发生率和冠状动脉损害率均较低,但差异无统计学意义(P>0.05)。结论与常规剂量比较,临床运用大剂量丙种球蛋白对小儿川崎病进行治疗,可缩短康复时间,且无严重并发症发生,具有较高的有效性和安全性。

Objective To study the clinical effects and optimal dose of gamma globulin in the treatment of Kawasaki disease.Methods 108 cases of Kawasaki patients in our hospital from August 2010 to August 2015 were selected as the study objects,which were divided into two groups according the odd and even number of hospitalization number.The observation group was treated with high dose of gamma globulin,and the control group was treated with conventional dose.The treatment effects,clinical symptoms disappeared time and adverse reactions incidences in two groups were compared and analyzed.Results Compared with the control group,the total effective rate in the observation group is significantly higher（P〈0.05）.Furthermore,there were significant differences of the mucosal congestion,rash,hand-foot symptoms and swollen lymph nodes disappeared time between the two groups（P〈0.05）.Compared with the control group,the adverse reactions incidence and coronary artery lesions rate in the observation group were lower,but there were no significant difference between groups（P〉0.05）.Conclusion Compared with the conventional dose,the high-dose of gamma globulin for the Kawasaki disease not only can shorten the recovery time,but also reduce complications,with high efficiency and safety.