摘要
慢性肾脏病进展是多因素的,与肾小球损伤相比,以细胞外基质(ECM)积聚为特征的肾脏间质纤维化更能够反映肾脏疾病的进展。肾素-血管紧张素系统(RAS)的激活是肾间质纤维化的一个关键因素,其中,血管紧张素Ⅱ(AngⅡ)是其主要的促纤维化因子。AngⅡ介导肾间质纤维化依赖于多种机制。通过了解AngⅡ在肾间质纤维化中的作用机制,将为慢性肾脏病提供新的治疗策略。
The cause of progression for chronic kidney acterized by the accumulation of extraeellular matrix disease （CKD） is muhifactorial. Renal interstitial fibrosis char- （ECM）, is a better reveal of progression for CKD, compared to glomeruli damage. The activation of the renin-angiotensin system （RAS） is a key factor for renal interstitial fibrosis. Angiotensin Ⅱ （AngⅡ）, the main effector of RAS, is a critical promoter of fibrogenesis, the mechanisms underlying its profibrogenic effects are complex. A better understanding of the effects of Ang Ⅱ for renal interstitial fibrosis, will con- tribute to developing better strategies for the CKD.
出处
《中国医药导报》
CAS
2017年第2期29-32,共4页
China Medical Herald
基金
国家自然科学基金青年基金项目(81500516)
