摘要
目的:探索蛋白E-cad、CD44s在大鼠舌黏膜癌变过程中的表达变化。方法:屏障环境下4NQO饮水法诱导SD大鼠舌黏膜癌变,采用免疫组化法检测82例大鼠舌黏膜标本组织中E-cad、CD44s的表达情况。结果:在大鼠舌黏膜癌变过程中,E-cad表达下降、CD44s表达上升,E-cad、CD44s的表达差异有统计学意义(P<0.05)。相关性分析表明E-cad与CD44s表达呈负相关,相关性有统计学意义(rs=-0.675,P<0.001)。结论:E-cad和CD44s在舌鳞癌的发生、发展中起了一定的作用,联合检测E-cad和CD44s的表达可能为临床早期诊断提供新的方法。
Objective：To explore the expression of E-cad and CD44 sin the rat tongue carcinogensis.Methods：The water drinking method of 4NQO was used in a barrier system to induce tongue carcinogensis of SD rats.Immunohistochemical technique was used to study the expression of E-cad and CD44 sin 82tissue specimens of rat tongue carcinogensis.Results：In the process of rat tongue carcinogensis,the expression of E-cad decreased while that of CD44 sincreased,and the differences in the expression of E-cad and CD44 swere statistically significant for each group（P〈0.05）.The expression of E-cad had a significantly negative correlation with CD44sexpression（rs=-0.675,P〈0.001）.Conclusion：E-cad and CD44 swere involved in the occurrence and development of tongue squamous cell carcinoma,and combined detection of CD44 sand E-cad may provide a new method for early clinical diagnosis.
出处
《口腔医学研究》
CAS
北大核心
2017年第2期158-161,共4页
Journal of Oral Science Research
基金
四川省科技厅(编号:2014LY-62)
