正常人脑~1H-MRS代谢产物定量的相关影响因素分析

Analysis Aboutaffected Factors in quantitative ~1H Magneticresonance Spectroscopy Metabolite Concentrationsin Healthy Adults

目的探讨不同回波时间(TE)、受检者年龄、性别、侧别对正常成人脑1H-MRS额叶及基底节区磁共振波谱(magneticresonance spectroscopy MRS)代谢物定量的影响。方法通过对17位健康志愿者(20-60岁)采用多体素点分辨波谱(PRESS)序列进行1H-MRS检查,TE分别采用30ms、135ms,对比双侧额叶及基底节区同一感兴趣区NAA/Cr,Cho/Cr值,并且按照TE、年龄、性别、左右分组比较各组间结果。结果 (1)TE为135时可以获得更高质量的图像;长、短TE两组间左右额叶及基底节区NAA/Cr比值及左右基底节区Cho/Cr比值对比有显著性差异。(2)在同一TE参数下,左右额叶对称部位感兴趣区NAA/Cr值对比有显著差异,而性别对波谱代谢物相对定量值的无显著影响;(3)双侧额叶NAA/CR及右侧基底节区NAA/CR值与年龄呈显著负相关。结论不同回波时间、年龄及侧别对MRS代谢物会产生影响,而性别对MRS代谢产物无影响。

Objective To investigate the effect of echo time, age, gender and the difference between right and left on metabolite quantity in front lobe and basal ganglia of MR spectroscopy in healthy adults. Methods MRS were employed in 17 right-handed healthv volunteers （5 male and 12 female, age range 20～60years, average age 48.5 ± 16.5） used multi-voxel PRESS sequence with diffent TE（30ms and 135ms）.Voxels were selected at the same areas of bilateral frontal white matter and basal ganglia, N-acetylaspartate（NAA）, choline-containing compounds（Cho） and creatine（Cr） and NAA/Cr Cho/Cr were measured. And compared each statistical index between right and left, male and female. Results （1） We could got higher quality imagingsused PRESS135.And the NAA/Cr ratios in the frontal white matter and basal ganglia using PRESS135 and Ptt.ESS35 sequence had significant difference. However, there had no difference between them about the concentrations of Cho/Cr in the basal ganglia. （2） The NAA/Cr had significant difference between right and left frontal white matter at the same TEs. However, no significant gender effects were found in the concentrations and their ratios. （3）Significant negative-correlation between age and NAA/Cr ratios were observed in the bilateral frontal white matter and right basal ganglia area. Conclusion This study demonstrated that different echo time, age laterality differences may affect the metabolicratios measured by MR spectroscopy, but there had no gender differences in both side of frontal white matter and right basal ganglia.