中药金疮油膏治疗难治性压疮临床疗效观察

Clinical Effect of Treating Refractory Pressure Ulcers by Jinchuang Ointment

目的观察中药金疮油膏治疗难治性压疮患者的临床疗效。方法将306例Ⅱ、Ⅲ、Ⅳ期压疮患者随机分为传统压疮膏组、金疮油膏组、美皮康银组3组,每组102例,分别于治疗前、治疗后第7、14、21天使用美国压疮专家顾问组(National Pressure Ulcer Advisory Panel,NPUAP)设计的压疮愈合评分表(pressure ulcer scale for healing,PUSH)对每处压疮进行评分,观察第21天创面愈合率。结果与本组治疗前比较3组患者压疮创面PUSH评分在治疗后7、14、21天差异均有统计学意义(P<0.01),而治疗后14、21天,金疮油膏组优于传统压疮膏组和美皮康银组(P<0.05),传统压疮膏组和美皮康银组两组比较,差异无统计学意义(P>0.05)。结论中药金疮油膏治疗Ⅱ、Ⅲ、Ⅳ期压疮患者均有显著疗效,其14、21天创面愈合率明显高于传统压疮油膏和美皮康银。

Objective To observe the clinical effect of Jinchuang Ointment（ JO） for treatment of refractory pressure ulcers. Methods Totally 306 patients with phase Ⅱ,Ⅲ,Ⅳ refractory pressure ulcers were randomly assigned to the traditional Chinese herbal medicine ointment group,the JO group,the Mepilex Ag group,102 cases in each group. Each ulcer was scored using pressure ulcer scale for healing（ PUSH） designed by National Pressure Ulcer Advisory Panel（ NPUAP） before treatment,at day 7,14,and 21 after treatment,respectively. The healing rate of pressure ulcer was observed at day 21. Results There was significant difference in PUSH score of the 3groups between before treatment and at day 7 /14 /21 after treatment（P〈0. 01）. PUSH score was better in the JC group,as compared with that in the other two groups（P〈0. 05） at day 14 and 21 after treatment. There was no significant difference in PUSH score between the traditional Chinese herbal medicine ointment group and the Mepilex Ag group（P〉0. 05）. Conclusions JO had significant effect in treatment of patients with phase Ⅱ,Ⅲ,Ⅳ pressure ulcers. The rate of wound healing at day 14 /21 was significantly higher than that of traditional Chinese herbal medicine ointment and Mepilex Ag.