齐拉西酮联合舍曲林治疗难治性精神分裂症患者的疗效

Curative Effect Observation on Ziprasidone Combined with Sertraline in the Treatment of Refractory Schizophrenia

目的观察齐拉西酮联合舍曲林治疗难治性精神分裂症患者的疗效。方法选取2014年4月至2015年9月医院收治的70例难治性精神分裂症患者,随机分为两组,各35例。对照组采用单纯齐拉西酮治疗,试验组在对照组治疗基础上加用舍曲林,比较两组治疗有效率及不良反应发生率。结果试验组治疗有效率(68.57%)高于对照组(57.14%),差异有统计学意义(P<0.05);试验组嗜睡、便秘、心动过速、流涎等不良反应发生率均明显低于对照组,差异有统计学意义(P<0.05)。结论齐拉西酮联合舍曲林治疗难治性精神分裂症患者临床疗效显著,可有效控制患者的病情,安全性高,在临床应用中值得推广。

Objective To analyze the clinical efficacy of ziprasidone combined with sertraline in the treatment of refractory schizophrenia. Methods 70 patients with refractory schizophrenia admitted into the hospital from April 2014 to September 2015 were randomly divided into two groups, 35 patients in each. The control group was treated with ziprasidone treatment, observation group in the control group were treated with ser-traline. The effective rate and adverse reactions of two groups were compared. Results The effective rate of observation group was higher than that of control group （P 〈0. 05） ; The incidence rate of adverse reactions in the observation group was 57.14% , significantly lower than that of the con-trol group 68. 57% （P 〈0. 05） . Conclusion Ziprasidone combined with sertraline for treating refractory schizophrenia, has significant clinical effica-cy and it can effectively control patients5 condition, which has high safety and is worthy of generalization in clinical application.