哌拉西林/舒巴坦联合盐酸氨溴索治疗2型糖尿病并肺部感染临床疗效观察

Clinical curative effect observation of piperacillin/sulbactam combined with ambroxol hydrochloride in the treatment of type 2 diabetes and pulmonary infection

目的探讨哌拉西林/舒巴坦联合盐酸氨溴索治疗2型糖尿病并肺部感染的临床疗效。方法选取2013年6月至2016年3月期间我院收治的338例2型糖尿病并肺部感染患者,随机分为观察组163例和对照组175例。对照组采用哌拉西林/舒巴坦治疗,观察组采用哌拉西林/舒巴坦联合盐酸氨溴索治疗。比较两组患者的临床疗效和治疗前后的各项临床症状指标变化。结果治疗前,两组患者的降钙素原(PCT)、C反应蛋白(CRP)、1秒用力呼气容积/预期值(FEV1/预期值)、1秒用力呼气容积/用力肺活量(FEV1/FVC)比较差异无统计学意义(P>0.05);治疗后,两组患者的PCT、CRP明显降低,FEV1/FVC、FEV1/预期值显著升高,观察组PCT、CRP水平低于对照组,FEV1/FVC、FEV1/预期值大于对照组,差异有统计学意义(P<0.05);观察组治疗有效率大于对照组,差异有统计学意义(P<0.05);两组患者不良反应差异无统计学意义(P>0.05)。结论哌拉西林/舒巴坦联合盐酸氨溴索治疗2型糖尿病并肺部感染疗效显著,值得推广使用。

Objective To analyze clinical efficacy of piperacillin/sulbactam combined with ambroxol hydrochloride in the treatment of type 2diabetes and pulmonary infection.Methods A total of338 patients with type 2diabetes mellitus and pulmonary infection in our hospital from June 2013 to March 2016 were selected and divided into observation group（163cases）and control group（175cases）.Control group was treated with piperacillin/sulbactam,and observation group was treated with piperacillin/sulbactam combined with ambroxol hydrochloride treatment.The clinical efficacy and the changes of the clinical symptoms of the two groups before and after the treatment were analyzed and compared.Results Before treatment,the two groups of patients with PCT,CRP,FEV1/expected value,FEV1/FVC had no statistical significance（P0.05）;after treatment,two groups of patients with PCT and CRP were significantly lower,FEV1/FVC,FEV1/expected values increased significantly,observation group of patients with PCT and CRP levels were lower than those of the control group,FEV1/FVC,FEV1/expected value were greater than the control group,the difference was statistically significant（P0.05）;the effective rate of treatment in observation group was higher than in the control group,the difference was statistically significant（P0.05）;the adverse reactions of patients in two groups were no statistical significance（P0.05）.Conclusion The curative effect of piperacillin/sulbactam combined with ambroxol hydrochloride in the treatment of type 2diabetes and lung infection is significant,worthy to be popularized.